Holding(s) in Company

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Synergy Healthcare PLC

2. Reason for notification  (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

An event changing the breakdown of voting rights

Other (please specify):______________

 X

3. Full name of person(s) subject to notification obligation:

Newton Investment Management Limited

4. Full name of shareholder(s) (if different from 3):

5. Date of transaction (and date on which the threshold is crossed or reached if different):

6. Date on which issuer notified:

14/07/08

7. Threshold(s) that is/are crossed or reached:

Increase from 5.87% to 6.26%

8: Notified Details Due  to a decrease in the company's share capital, Newton's % ownership of the company has increased. This change is not due to any market transactions.

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

Number of voting rights

Number of shares Direct

Number of voting rights

Percentage of voting rights

Direct

Indirect

Direct

Indirect

Ordinary Shares

ISIN

GB0030757263

3,342,026

5.87%

N/A

N/A

3,339,526

N/A

6.26%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date 

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

3,339,526

6.26%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Newton Investment Management Limited hold these shares as a discretionary Investment Manager.

Proxy Voting:

10. Name of proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

14 Contact name:

Asif S Lalani

15. Contact telephone name:

+44 (0) 20 7163 5115