Holding(s) in Company

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Ark Therapeutics Group Plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

YES

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

YES

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

J O HAMBRO CAPITAL MANAGEMENT LIMITED

4. Full name of shareholder(s)  (if different from 3.):iv

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

27 FEBRUARY 2015

6. Date on which issuer notified:

02 MARCH 2015

7. Threshold(s) that is/are crossed orreached: vi, vii

BELOW 5%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

GB00BSZLMS59

206594

206594

166007

166007

1.19%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

Total (A+B)

Number of voting rights

Percentage of voting rights

166007

1.19%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

NOT APPLICABLE

Proxy Voting:

10. Name of the proxy holder:

-

11. Number of voting rights proxy holder will ceaseto hold:

-

12. Date on which proxy holder will cease to holdvoting rights:

-

13. Additional information:

-

14. Contact name:

F Nicolaou

15. Contact telephone number:

0207 747 8971