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Holding(s) in Company

19th Mar 2008 11:29

Tissue Science Laboratories PLC19 March 2008 TR-1: Notifications of Major Interests in Shares 1. Identity of the issuer or the underlying Tissue Science Laboratories plcissuer of existing shares to which voting rights are attached: 2. Reason for notification (yes/no) An acquisition or disposal of voting rights YES An acquisition or disposal of financial instruments which may resultin the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify):______________ 3. Full name of person(s) subject to Covidien UK Holding Ltdnotification obligation: 4. Full name of shareholder(s) (ifdifferent from 3): 5. Date of transaction (and date on 18 March 2008which the threshold is crossed or reached if different): 6. Date on which issuer notified: 19 March 2008 7. Threshold(s) that is/arecrossed or reached: 14% 8: Notified Details A: Voting rights attached to shares Class/type of Situation previous to the triggering transactionsharesIf possible useISIN codeGB0030978380 Number of shares Number of voting rights 4,798,427 4,798,427 Resulting situation after the triggering transaction Number of shares Number of voting rights Percentage of voting rights 4,878,427 Direct Indirect Direct Indirect 4,878,427 14.1% B: Financial InstrumentsResulting situation after the triggering transactionType of Expiration date Exercise/ No. of voting Percentage offinancial conversion rights that may be voting rightsinstrument period/date acquired (if the instrument exercised/ converted) Total (A+B)Number of voting rights Percentage of voting rights 4,878,427 14.1% 9. Chain of controlled undertakings through which the voting rights and /or thefinancial instruments are effectively held, if applicable:Covidien UK Holding Ltd is an in-direct wholly owned subsidiary of Covidien Ltd Proxy Voting: 10. Name of proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: 14 Contact name: Mark Culwick 15. Contact telephone name: 0121 600 5227 This information is provided by RNS The company news service from the London Stock Exchange

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