Holding(s) in Company

21st Feb 2007 07:30

SR Pharma plc

Holding in Company

London, UK, 21 February 2007 - SR Pharma plc, the Company, announces that it received notification yesterday that following recent acquisitions;

* Cantor Fitzgerald Europe are the beneficial owners of 3,420,000 shares in the Company, representing 3.02% of the Company's issued share capital, and * Man Financial Limited are the beneficial owners of 5,995,200 shares in the Company, representing 5.30% of the Company's issued share capital. - Ends - Notes to EditorsSR Pharma (www.srpharma.com)

SR Pharma plc is a European biopharmaceutical company, listed on AIM. The Company has two operating subsidiaries Atugen AG (www.atugen.com) based in Berlin, Germany and Stanford Rook Ltd based in London, UK.

SR Pharma is a leader in RNAi therapeutics, which is a Nobel Prize winning technology that "silences" genes linked to the onset of disease. The Company has developed novel, chemically modified proprietary siRNA molecules ("AtuRNAi"), which have a number of advantages over conventional siRNA molecules including enhanced stability against nuclease degradation. In addition, the Company has developed a proprietary delivery system ("AtuPLEX"), which increases bioavailability, circulation times and functional intracellular uptake of siRNA molecules.

SR Pharma expects to begin the clinical development of its proprietary AtuRNAi therapeutic molecules for systemic cancer indications in 2007. SR Pharma has sublicensed the AtuRNAi compound RTP-801i to Pfizer through its collaboration partner Quark Biotech Inc. for the treatment of AMD and a number of other indications. This compound entered the clinic in early 2007. In addition SR Pharma has licensed a further AtuRNAi compound, PFTi, to Quark Biotech Inc., which should enter clinical trials for acute renal failure in 2007.

SR Pharma also owns a proprietary Mycobacterium vaccae-based technology and related products. Currently the Company is in discussions with third parties regarding the co-development and out-licensing of these products.

Forward-Looking Statements

This press release includes forward-looking statements that are subject to risks, uncertainties and other factors. These risks and uncertainties could cause actual results to differ materially from those referred to in the forward-looking statements. All forward--looking statements are based on information currently available to SR Pharma and SR Pharma assumes no obligation to update any such forward-looking statements.

Enquiries:

For further information, please contact the following:

SR Pharma plc Citigate Dewe Rogerson +44(0)20 7307 1620 +44(0)20 7638 9571 Iain Ross, Chairman David Dible

Melvyn Davies, Finance Director Valerie Auffray

Yvonne Alexander Atugen AG +49(0)30 9489 2800

Thomas Christĩly, Chief Executive Officer

Dr. Klaus Giese, Chief Scientific Officer

SR PHARMA PLC

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