Holding(s) in Company

TR-1 : NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii

ASTRAZENECA PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation: iii

Invesco Limited

4. Full name of shareholder(s)  (if different from 3.):iv

5. Date of the transaction and date on which the threshold is crossed or reached: v

25 September 2009

6. Date on which issuer notified:

29 September 2009

7. Threshold(s) that is/are crossed or reached: vi, vii

5%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type of shares

if possible using the ISIN CODE

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of Shares

Number of Voting Rights

Number of shares

Number of voting rights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

ORD USD 0.25

71,350,087

71,350,087

72,776,277

5.02%

GB0009895292

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date xiii

Exercise/ Conversion Period xiv

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date xvii

Exercise/ Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

72,776,277

5.02%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

ABN Amro Bank - 107,707

Brown Brothers Harriman (Jersey) - 139,464

Bank of Ireland (Dublin) - 211,751

Bank of New York - 57,484,090

Banque Paribas - 93,520

Banque Paribas (Frankfurt) - 86,507

Bank of New York (Brussels) - 21,624

Bank of New York (Singapore) - 10,612

Boston Safe Deposit - 31,088

Chase Bank - 84,396

JP Morgan Chase - 821,587

Chase (Frankfurt) - 80,337

Citibank Luxembourg - 3,862

Citibank New York - 6,405

Citibank - 202,156

Credit Agricole Indosuez - 218,865

Credit Agricole Indosuez (Luxembourg) - 66,700

Deutsche Bank UK - 10,073

Erst Group Bank AG (Austria) - 46,096

HSBC Bank Plc (London) - 21,893

Japan Trustee Services Bank - 12,910

KAS Bank, Amsterdam - 47,031

Landersbank Hessen-Thuringen Girozentrale - 10,288

Mellon Bank, Pittsburgh - 395,588

B.Metzler seel.Sohn & Co.KG (Frankfurt) - 19,377

Morgan Stanley (London) - 21,833

Master Trust Bank JP - 18,245

National Custody Services AU - 4,935

Nomura Trust & Banking JP - 8,437

State Street (Sydney) - 1,155

State Street Trust & Banking Co (Boston) - 37,299

State Street Trust & Banking Co (Hong Kong) - 23,928

State Street Trust & Banking Co (London) - 8,035,348

Trust & Custody Services JP - 2,263

Northern Trust Company London - 854,287

UBS Zurich - 42,590

Vorarlberger Landes-Und Hypothekenbk Akti - 633

ADR's - 679,538

Invesco PowerShares Capital Management - 19,834 

Invesco Global Asset Management NA Inc - 1,555,366

Invesco Hong Kong Limited - 11,767

Invesco Asset Management (Japan) - 31,132

Invesco National Trust Company & Invesco Global Asset Management Inc - 179,104

Invesco Global Asset Management (NA) Inc - 595,623 

Invesco Institutional NA Inc - 87,329

Other - 331,704

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

Samantha Edwards

15. Contact telephone number:

01491 416381

Note: Annex should only be submitted to the FSA not the issuer

Annex: Notification of major interests in share

A: Identity of the persons or legal entity subject to the notification obligation

Full name 

(including legal form of legal entities)

Contact address 

(registered office for legal entities)

Phone number & email

Other useful information 

(at least legal representative for legal persons)

B: Identity of the notifier, if applicable

Full name

Invesco Limited

Contact address

Registered address:

30 Finsbury Square, London. EC2A 1AG

Phone number & email

020 7638 0731

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information

For notes on how to complete form TR-1 please see the FSA website.