Holding(s) in Company

For filings with the FCA include the annex

For filings with issuer exclude the annex

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Sphere Medical Holding plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

P

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

Herald Investment Management Limited

4. Full name of shareholder(s)  (if different from 3.):iv

Discretionary investment management clients of Herald Investment Management Limited

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

1st May, 2015

6. Date on which issuer notified:

5th May, 2015

7. Threshold(s) that is/are crossed orreached: vi, vii

5%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Indirect

Direct xi

Indirect xii

Direct

Indirect

GB00B551W951

4,711,965

4,711,965

4,711,965

4,711,965

3.32%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

None

Nil

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

None

Nominal

Delta

Nil

Total (A+B+C)

Number of voting rights

Percentage of voting rights

4,711,965

3.32%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

N/A

Proxy Voting:

10. Name of the proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

14. Contact name:

Andrew Miller CFO

15. Contact telephone number:

020 7553 6308

Note: Annex should only be submitted to the FCA not the issuer

Annex: Notification of major interests in share

A: Identity of the persons or legal entity subject to the notification obligation

Full name

(including legal form of legal entities)

Herald Investment Management Limited

Contact address

(registered office for legal entities)

10/11 Charterhouse Square

London EC1M 6EE

Phone number & email

020 7553 6308

Other useful information

(at least legal representative for legal persons)

Andrew Miller CFO

B: Identity of the notifier, if applicable

Full name

See above

Contact address

Phone number & email

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information

We have used the figure of 141,757,872 announced to the market by the company via RNS on 29th April 2015 for total ordinary shares which will be in issue following the recent placing and open offer to calculate the percentage of voting rights held.

For notes on how to complete form TR-1 please see the FCA website.