Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii

Synairgen Plc

Sedol B0381Z2

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

Participation in placing

√

3. Full name of person(s) subject to the notification obligation: iii

¹Lansdowne Partners Limited being the General Partner of Lansdowne Partners Limited Partnership

²Lansdowne Partners International Limited

4. Full name of shareholder(s)  (if different from 3.):iv

 Morstan Nominees Ltd (Registered Shareholder)

5. Date of the transaction and date on which the threshold is crossed or reached: v

19/06/09

6. Date on which issuer notified:

22/06/09

7. Threshold(s) that is/are crossed or reached: vi, vii

10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type of shares

if possible using the ISIN CODE

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of Shares

Number of Voting Rights

Number of shares

Number of voting rights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

Ordinary Shares

1,950,000

1,950,000

11,949,037

0.00%

19.99%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date xiii

Exercise/ Conversion Period xiv

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date xvii

Exercise/ Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

11,949,037

19.99%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

Lansdowne Partners International Limited is the parent undertaking of Lansdowne Partners Limited.

Proxy Voting:

10. Name of the proxy holder:

Lansdowne Partners Limited

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

Andrea Taylor

15. Contact telephone number:

+44 20 7408 8508