Holding(s) in Company

21st Mar 2007 07:00

Proteome Sciences Plc ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

Revised due to DTR rules - see section 13

3. Full name of person(s) subject to the notification obligation:

FMR Corp

4. Full name of shareholder(s) (if different from 3):

Fidelity Management & Research Company (FMRCO)

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

Revised due to DTR rules

6. Date on which issuer notified:

20 March 2007 (by fax & post)

7. Threshold(s) that is/are crossed or reached:

N/A

8. Notified details:

A: Voting rights attached to shares

Class/type of Situation Resulting situation after the triggering shares previous to transaction Triggering if possible transaction Notification required under DTR transitional using ISIN provision 7 CODE Number Number Number Number of voting % of voting rights of of of rights Shares Voting shares Rights Direct Direct Indirect Direct Indirect Ordinary 780,842 780,842 780,842 0.59% shares GB0003104196 B: Financial InstrumentsResulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of voting financial date Conversion rights that may rights instrument Period/ Date be acquired if the instrument is exercised/ converted NIL Total (A+B)Number of voting rights % of voting rights 780,842 0.59%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

FMR CorpFMRCO10. Name of the Proxy holder:FMR Corp

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

As discussed with the FSA, prior to the implementation of the EU Transparency Directive, we aggregated the interests in shares of FMR Corp (FMR) and Fidelity International Limited (FIL). According to the new DTR rules we are now reporting the indirect holdings of FMR and FIL separately. A separate notification is being submitted for FIL Corp. Please note these holdings are correct as of close of business 16 March 2007.

14. Contact name:

Christopher Pearce or James Malthouse 01932 865065

Proteome Sciences PLCThilo Hoffmann 020 7426 9000Teather & Greenwood Limited15. Contact telephone number:

PROTEOME SCIENCES PLC

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Related Shares:

Proteome