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Holding(s) in Company

26th Jan 2010 16:00

Notification of major interests in shares

January 26, 2010 - Shire plc

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Shire plc

2. Reason for the notification State Yes/No An acquisition or disposal of voting rights Yes

An acquisition or disposal of qualifying financial instruments No which may result in the acquisition of shares already issued to

which voting rights are attached

An acquisition or disposal of instruments with similar economic No effect to qualifying financial instruments

An event changing the breakdown of voting rights No Other (please specify): No

3. Full name of person(s) subject to the notification Invesco Limited obligation:

4. Full name of shareholder(s) (if different from 3.): N/A 5. Date of the transaction (and date on which the 21 January 2010 threshold is crossed or reached if different): 6. Date on which issuer notified: 22 January 2010 7. Threshold(s) that is/are crossed or reached: Below 3% 8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous to Resulting situation after the triggering

shares the Triggering transaction if possible transaction using the ISIN CODE Number Number Number Number of voting % of voting of of of rights rights Shares Voting shares Rights Direct Indirect Direct Indirect

Ord 5p Shares 17,479,662 17,479,662 N/A N/A 16,095,485 N/A 2.86% and ADR's 3:1

JE00B2QKY057

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of Expiration Exercise/ Number of voting % of voting financial date Conversion rights that may be rights instrument Period/ Date acquired if the instrument is exercised/ converted Delta

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of % of voting financial price date Conversion voting rights instrument period rights instrument refers to Nominal Total (A+B+C) Number of voting rights % of voting rights 16,095,485 2.86

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Invesco Trimark Ltd & AiM Advisors - 2,004,101 AiM Advisors Inc. - 9,269,548 AiM Capital Management Inc. - 1,218,698 Invesco Trimark Limited (Canada) - 131,000 Invesco Taiwan Limited - 6,400 Invesco Asset Management Limited - 10,959 Invesco GT Management S.A Lux & AiM Capital Management Inc. - 129,682 Invesco PowerShares Capital Management Ireland - 315 Invesco PowerShares Capital Management LLC - 2,564

ADR's 3,322,218 Proxy Voting: N/A 10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to N/A hold: 12. Date on which proxy holder will cease to hold voting N/A

rights: 13. Additional information: 14. Contact name: Samantha Edwards

15. Contact telephone number: 01491 416381

Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746

For further information please contact:

Investor Relations Cl©a Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 617 551 9715 Notes to editorsSHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

3Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

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