Holdings in Company

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

ARIX BIOSCIENCE PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

 X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

Takeda Ventures, Inc.

4. Full name of shareholder(s)  (if different from 3.):iv

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

 17/02/2017

6. Date on which issuer notified:

02 March 2017

7. Threshold(s) that is/are crossed orreached: vi, vii

5%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

%of voting rightsx

Direct

Direct xi

Indirect xii

Direct

Indirect

Ordinary Shares

GB00BD045074

0.00

0.00

4,830,917

4,830,917

5.4%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

N/A

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

N/A

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

4,830,917

5.4%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

Proxy Voting:

10. Name of the proxy holder:

none

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

Michael Martin, Ph.D.

15. Contact telephone number:

+1 650 328 2900

Annex: Notification of major interests in sharesxxii

A: Identity of the persons or legal entity subject to the notification obligation

Full name

(including legal form of legal entities)

Takeda Ventures, Inc.

Contact address

(registered office for legal entities)

435 Tasso Street, Suite 300 Palo Alto, CA 94301 USA

Phone number & email

Phone: +1 650 328 2900 E-mail: [email protected]

Other useful information

(at least legal representative for legal persons)

B: Identity of the notifier, if applicable

Full name

Michael Martin, Ph.D.

Contact address

435 Tasso Street, Suite 300 Palo Alto, CA 94301 USA

Phone number & email

Phone: +1 650 328 2900

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

President

C: Additional information