Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Smiths Group Plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

TIAA-CREF Investment Management, LLC on behalf of the accounts listed in Exhibit A attached hereto

Teachers Advisors, Inc. on behalf of the funds

Listed in Exhibit B attached hereto

4. Full name of shareholder(s)  (if different from 3.):iv

See Number 3

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

24 April 2012

6. Date on which issuer notified:

25 April 2012

7. Threshold(s) that is/are crossed orreached: vi, vii

Below 3%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

GB00B1WY2338

11,864,623

11,864,623

Below 3%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

N/A

N/A

N/A

N/A

N/A

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

N/A

N/A

N/A

N/A

N/A

Nominal

Delta

N/A

N/A

Total (A+B+C)

Number of voting rights

Percentage of voting rights

Below 3%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

The College Retirement Equities Fund ("CREF") hereby informs you that on April 24, 2012, CREF holds 5,939,092 shares of Smiths Group Plc. CREF owns these shares through three of its investment accounts, the Stock Account, Global Equities Account and Social Choice Account. It is our understanding the total voting shares outstanding of Smiths Group Plc are 392,622,866 bringing CREF's ownership in your company to a 1.513% level.

For your information, CREF is a U.S. based investment company, which is registered with the Securities and Exchange Commission ("SEC"). CREF has multiple investment accounts, each with separate investment objectives and policies. All assets in the accounts are beneficially owned by CREF, and all the accounts are managed by TIAA-CREF Investment Management, LLC, an SEC registered investment adviser.

Additionally, on April 24 2012 affiliates of CREF sold some of its shares of Smiths Group Plc bring its total holdings in your company to 5,677,233 shares. These holdings are owned by the TIAA-CREF Funds ("Funds"), and the TIAA-CREF Life Funds ("Life Funds"), each of which are SEC registered investment companies. The Funds and Life Funds are managed by Teachers Advisors, Inc., an SEC registered investment adviser that is affiliated with TIAA-CREF Investment Management, LLC. These affiliated funds, aggregated with those of CREF, own a total of less than 3% of the outstanding voting shares of your company. Because Teachers Advisors, Inc. and TIAA-CREF Investment Management, LLC follow the same policies when voting these funds, we are aggregating the holdings for purposes of this letter.

Proxy Voting:

10. Name of the proxy holder:

TIAA-CREF Investment Management, LLC/ Teachers Advisors, Inc.

11. Number of voting rights proxy holder will ceaseto hold:

N/A

12. Date on which proxy holder will cease to holdvoting rights:

N/A

13. Additional information:

None

14. Contact name:

Stuart R. Brunet

15. Contact telephone number:

+1-415-882-3711