Holding(s) in Company

For filings with the FSA include the annexFor filings with issuer exclude the annex 

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences plc

2. Reason for notification

[Yes/No]

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

No

An event changing the breakdown of voting rights

No

Other (please specify):

No

3. Full name of person(s) subject to notification obligation:

Cubana Investments Limited

4. Full name of shareholder(s) (if different from 3):

5. Date of transaction (and date on which the threshold is crossed or reached if different):

20 March 2009

6. Date on which issuer notified:

23 March 2009

7. Threshold(s) that is/are crossed or reached:

>10%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

If possible use ISIN code

Number of shares

Number of voting rights

Number of shares

Number of voting rights

Percentage of voting rights

Direct

Indirect

Direct

Indirect

GB0003104196

11,987,468

11,987,468

13,287,183

13,287,183

-

10.01%

-

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

13,287,183

10.01%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14 Contact name:

James Malthouse

15. Contact telephone name:

+44 1932 865065