Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Plethora Solutions Holdings plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

x

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

Baker Bros. Advisors LP

4. Full name of shareholder(s)  (if different from 3.):iv

Baker Brothers Life Sciences, L.P. and 667, L.P.

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

November 5, 2015

6. Date on which issuer notified:

November 9, 2015

7. Threshold(s) that is/are crossed orreached: vi, vii

Below 8%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

GB00B06GL868

66,631,385

66,631,385

65,381,385

35,381,385

7.94%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

Warrant to purchase

ordinary shares at

£0.15

September 19, 2019

5 years

28,619,528

3.36%

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

Number of voting rights 94,000,913

Percentage of voting rights 11.03%*

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

Baker Bros. Advisors LP (the "Adviser") is the investment adviser of Baker Brothers Life Sciences, L.P.,

and 667, L.P. (collectively, the "Funds") and, pursuant to management agreements between the Adviser, the

Funds and the respective general partners of the Funds, has complete and unlimited discretion and authority

with respect to the Funds' investments and voting power over investments.

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will ceaseto hold:

12. Date on which proxy holder will cease to holdvoting rights:

13. Additional information:

14. Contact name:

Alexandra A. Toohey, Chief Financial Officer

15. Contact telephone number:

+1-212-339-5690