Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

e-Therapeutics plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

X

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

Octopus Investments Limited

4. Full name of shareholder(s)  (if different from 3.):iv

Octopus Titan VCT 1 plc.

Octopus Titan VCT 2 plc.

Octopus Titan VCT 3 plc.

Octopus Investments Nominees Limited

Octopus Capital Limited

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

04 March 2011

6. Date on which issuer notified:

09 March 2011

7. Threshold(s) that is/are crossed orreached: vi, vii

5% and 6%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

Ordinary shares

GB00B2823H99

3,138,108

3,138,108

8,768,508

8,768,508

n/a

6.4%

n/a

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

n/a

n/a

n/a

n/a

n/a

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

n/a

n/a

n/a

n/a

n/a

Nominal

Delta

n/a

n/a

Total (A+B+C)

Number of voting rights

Percentage of voting rights

8,768,508

6.4%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

Octopus Investments Limited is the investment manager to:

Octopus Titan VCT 1 plc

Octopus Titan VCT 2 plc

Octopus Titan VCT 3 plc.

Octopus Investments Limited is the parent company to:

Octopus Investments Nominees Limited

Octopus Investments is the wholly owned fund management subsidiary of:

Octopus Capital Limited

Proxy Voting:

10. Name of the proxy holder:

n/a

11. Number of voting rights proxy holder will ceaseto hold:

n/a

12. Date on which proxy holder will cease to holdvoting rights:

n/a

13. Additional information:

14. Contact name:

Mikko Nahkuri

15. Contact telephone number:

020 7710 2849 / 2879