Holding(s) in Company

Notification of major interests in shares October 31, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1. Identity of the issuer or the underlying issuer of existing shares to Shire plcwhich voting rights are attached: 2. Reason for the notification State Yes/ No An acquisition or disposal of voting rights Yes An acquisition or disposal of qualifying financial instruments which mayresult in the acquisition of shares already issued to which voting rightsare attached No An acquisition or disposal of instruments with similar economic effect toqualifying financial instruments No An event changing the breakdown of voting rights No Other (please specify): No 3. Full name of person(s) subject to the notification obligation: FMR LLC 4. Full name of shareholder(s) (if different from 3.): See Section 9 5. Date of the transaction (and date on which the threshold is 30th October 2014crossed or reached if different): 6. Date on which issuer notified: 31st October 2014 7. Threshold(s) that is/are crossed or reached: 5% 8. Notified details: A: Voting rights attached to shares Situation previous to Resulting situation after the triggering the Triggering transactionClass/type transactionof shares if possible Number Number Number Number of voting % of votingusing the of of of rights rightsISIN CODE Shares Voting shares Rights Indirect Direct Indirect Direct Indirect JE00B2QKY057 29,221,937 29,221,937 29,648,433 29,648,433 5.02 B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % offinancial date Conversion rights that may be votinginstrument Period/ Date acquired if the rights instrument is exercised/converted C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of % of votingfinancial price date Conversion voting rightsinstrument period rights instrument refers to Nominal Delta Total (A+B+C) Number of voting rights % of voting rights 29,648,433 5.02 9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: Custodian Day to Day IM Total CROSBY ADVS LLC-CROSBY ADVISORS LLC 16,700 BANK OF NEW YORK MELLON FMRC-FMR CO., INC 18,800 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 160,094 BROWN BROTHERS HARRIMAN AND CO FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC. 42,900 FMRC-FMR CO., INC 6,548,374 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 16,530 PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 264,879 CIBC MELLON TRUST (C) PGA ULC-PYRAMIS GLOBAL ADVISORS (CANADA) ULC 38,200 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 6,523 PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 13,200 CITIBANK NA FMRC-FMR CO., INC 3,724,065 CITIBANK NA, HONG KONG BR (S) PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 7,197 DEUTSCHE BANK ALEX BROWN (C) PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 3,600 GOLDMAN SACHS AND CO PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 7,200 JP MORGAN, BOURNEMOUTH (C) PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 3,257 PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 16,395 JPMORGAN CHASE BANK FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC. 422,700 FMRC-FMR CO., INC 7,704,519 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 900 PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 13,523 SELECTCOLLC-FIDELITY SELECTCO, LLC 150 MELLON BANK NA (C) PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 48,242 MORGAN STANLEY AND CO LLC PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 1,200 NATIONAL BANK TRUST (C) PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 6,880 NATIONAL FINANCIAL SERVICES(C) SAI-STRATEGIC ADVISERS, INC. 1,603 NORTHERN TRUST CO (C) FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC. 1,110,100 FMRC-FMR CO., INC 1,972,600 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 88,401 PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 11,550 ROYAL TRUST- TORONTO (C) PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 4,043 STATE STR BK AND TR CO LNDN (C PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 5,172 STATE STREET BANK AND TR CO FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC. 532,100 FMRC-FMR CO., INC 5,960,380 PGA ULC-PYRAMIS GLOBAL ADVISORS (CANADA) ULC 504,500 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 228,057 PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY 136,032 US BANK NA (C) PGALLC-PYRAMIS GLOBAL ADVISORS, LLC 7,868 Grand Total 29,648,433 Proxy Voting: 10. Name of the proxy holder: FMR LLC 11. Number of voting rights proxy holder will acquire: 426,496 12. Date on which proxy holder will acquire voting rights: 30th October 2014 13. Additional information: None 14. Contact name: Nina Collomosse 15. Contact telephone number: [email protected], 01737 837092 Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746 For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology.

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