9th Mar 2009 12:00
Notification of major interests in shares
March 9, 2009 - Shire plc , the global specialty biopharmaceutical company
1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:
Shire plc 2. Reason for the notification State Yes/No An acquisition or disposal of voting rights Yes
An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached
An event changing the breakdown of voting rights Other (please specify):
3. Full name of person(s) subject to the notification Capital Group obligation:
International Inc 4. Full name of shareholder(s) (if different from 3.): 5. Date of the transaction (and date on which the 5 March 2009 threshold is crossed or reached if different): 6. Date on which issuer notified: 6 March 2009 7. Threshold(s) that is/are crossed or reached: Above 3% 8. Notified details:
A: Voting rights attached to shares
Situation Resulting situation after the triggering previous to transaction the Triggering Class/type of transaction shares
if possible Number Number Number Number of voting % of voting using the ISIN of of of
rights rights CODE Shares Voting shares Rights Direct Indirect Direct Indirect Direct Indirect Ordinary Shares 7,952,700 7,952,700 1.4196% (JE00B2QKY057) Below 3% ADRs 3,211,770 9,635,310 1.7199% (US82481R1068) B: Financial Instruments
Resulting situation after the triggering transaction
Type of Expiration Exercise/ Number of voting % of financial date Conversion rights that may be voting instrument Period/ Date acquired if the rights instrument is exercised/converted Total (A+B)
Number of voting rights % of voting rights
17,588,010 3.1395%
9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:
Number of Percent of Shares Outstanding Capital Group International Inc (CGII) 17,588,010 3.140% Holdings Holdings by CGII Management Companies and Funds: Capital Guardian Trust Company 15,315,310 2.734% Capital International Limited 458,500 0.082% Capital International S.A 525,800 0.094% Capital International Inc 1,288,400 0.230% Proxy Voting:10. Name of the proxy holder: N/A
11. Number of voting rights proxy holder will cease to hold: N/A
12. Date on which proxy holder will cease to hold voting rights: N/A
13. Additional Notification using the total voting rights figures of information: 560,222,583 14. Contact name: Gina Martinez/Vivien Tan 15. Contact telephone (213) 615-0469 number:
Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746
For further information please contact:
Investor Relations Cl©a Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 617 551 9715 Notes to editors SHIRE PLC
Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.
For further information on Shire, please visit the Company's website: www.shire.com.
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