Holding in Company

For filings with the FSA include the annex

For filings with issuer exclude the annex 

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Biofutures International Plc

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

An event changing the breakdown of voting rights

Other (please specify):______________

3. Full name of person(s) subject to notification obligation:

Credit Agricole Cheuvreux International Ltd

4. Full name of shareholder(s) (if different from 3):

5. Date of transaction (and date on which the threshold is crossed or reached if different):

17/07/08

6. Date on which issuer notified:

21/07/08

7. Threshold(s) that is/are crossed or reached:

8%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date 

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

12,722,177

8.42%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

SAS Rue La Boétie

Crédit Agricole SA

Calyon SA

Crédit Agricole Cheuvreux SA

Crédit Agricole Cheuvreux International Limited 12,722,177 (8.42%)

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14 Contact name:

Anne McLeod

15. Contact telephone name:

0207 214 6518