Form 8.5 (EPT/RI)

(a) Name of exempt principal trader:

Citigroup Global Markets Limited

(b) Name of offeror/offeree in relation to whoserelevant securities this form relates:Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exemptprincipal trader is connected:

Shire plc

(d) Date dealing undertaken:

9 October 2018

(e) In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer?If it is a cash offer or possible cash offer, state "N/A"

YESTakeda Pharmaceutical Company Limited

Class of relevant security

Purchases/ sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

5p ordinary

Purchase

6,000

USD 0.0000

USD 0.0000

5p ordinary

Purchase

74,938

GBP 44.0000

GBP 43.5850

5p ordinary

Sale

6,000

USD 57.1579

USD 57.1579

5p ordinary

Sale

156,669

GBP 44.1200

GBP 43.5000

Class of relevant security

Product description e.g. CFD

Nature of dealinge.g. opening/closing along/short position,increasing/reducing along/short position

Number of reference securities

Price per unit

5p ordinary

TRS

Reducing Long Position

282

GBP 43.8349

5p ordinary

TRS

Reducing Long Position

451

GBP 43.8349

5p ordinary

TRS

Increasing Short Position

889

GBP 43.7900

5p ordinary

TRS

Reducing Short Position

206

GBP 43.7900

5p ordinary

TRS

SELECT

853

GBP 43.7918

5p ordinary

TRS

SELECT

2,836

GBP 43.8277

5p ordinary

TRS

SELECT

3,600

GBP 43.7900

5p ordinary

TRS

SELECT

10

GBP 43.7750

5p ordinary

TRS

SELECT

3,206

GBP 43.8116

5p ordinary

TRS

SELECT

48

GBP 43.8450

5p ordinary

TRS

SELECT

634

GBP 43.8229

5p ordinary

TRS

SELECT

9

GBP 43.8450

5p ordinary

TRS

SELECT

554

GBP 43.8158

5p ordinary

TRS

SELECT

1,539

GBP 43.8214

5p ordinary

TRS

SELECT

67

GBP 44.0000

5p ordinary

TRS

SELECT

116

GBP 44.0000

5p ordinary

TRS

SELECT

77

GBP 43.5851

5p ordinary

TRS

SELECT

17

GBP 44.0000

5p ordinary

TRS

SELECT

673

GBP 43.6292

5p ordinary

TRS

SELECT

289

GBP 43.9850

5p ordinary

TRS

SELECT

107

GBP 43.8950

5p ordinary

TRS

SELECT

5

GBP 43.5350

5p ordinary

TRS

SELECT

309

GBP 44.0600

5p ordinary

TRS

SELECT

46

GBP 43.8050

5p ordinary

TRS

SELECT

200

GBP 43.5050

5p ordinary

TRS

SELECT

70

GBP 43.8700

5p ordinary

TRS

SELECT

140

GBP 43.8850

5p ordinary

TRS

SELECT

290

GBP 44.0500

5p ordinary

TRS

SELECT

290

GBP 44.0000

5p ordinary

TRS

SELECT

8,073

GBP 43.8944

5p ordinary

TRS

SELECT

288

GBP 44.0650

5p ordinary

TRS

SELECT

289

GBP 43.9750

5p ordinary

TRS

SELECT

290

GBP 43.9950

5p ordinary

TRS

SELECT

289

GBP 44.1200

5p ordinary

TRS

SELECT

979

GBP 43.8798

5p ordinary

TRS

SELECT

289

GBP 43.9000

5p ordinary

TRS

SELECT

200

GBP 43.5350

5p ordinary

TRS

SELECT

764

GBP 43.7218

5p ordinary

TRS

SELECT

250

GBP 43.9950

5p ordinary

TRS

SELECT

11,075

GBP 43.9003

5p ordinary

TRS

SELECT

62

GBP 43.5000

5p ordinary

TRS

SELECT

289

GBP 43.9650

5p ordinary

TRS

SELECT

295

GBP 43.7550

5p ordinary

TRS

SELECT

16

GBP 43.6550

5p ordinary

TRS

SELECT

296

GBP 43.6000

5p ordinary

TRS

SELECT

10

GBP 43.5100

5p ordinary

TRS

SELECT

89

GBP 43.7900

5p ordinary

TRS

SELECT

3,600

GBP 43.8201

5p ordinary

TRS

SELECT

3,600

GBP 43.7900

5p ordinary

TRS

SELECT

1,413

GBP 43.6369

5p ordinary

TRS

SELECT

2,765

GBP 43.6620

5p ordinary

TRS

SELECT

29,121

GBP 43.6674

5p ordinary

TRS

SELECT

278

GBP 43.6651

5p ordinary

TRS

SELECT

6,000

USD 0.0000

5p ordinary

TRS

SELECT

33,577

GBP 43.6656

5p ordinary

TRS

SELECT

25,500

GBP 43.8931

5p ordinary

TRS

SELECT

200

GBP 44.0000

5p ordinary

TRS

SELECT

400

GBP 43.6594

5p ordinary

TRS

SELECT

350

GBP 43.5850

5p ordinary

TRS

Increasing Long Position

1,828

GBP 43.7900

5p ordinary

TRS

Reducing Short Position

29,764

GBP 43.7900

5p ordinary

TRS

Reducing Short Position

51,555

GBP 43.9572

Class of relevant security

Product description e.g. call option

Writing, purchasing,selling,varying etc.

Number of securities towhich option relates

Exercise price per unit

Typee.g. American,European etc.

Expiry date

Option money paid/ received per unit

Class of relevant security

Product description e.g. call option

Exercising/ exercised against

Number ofsecurities

Exercise price per unit

Class of relevant security

Nature of dealinge.g. subscription, conversion

Details

Price per unit(if applicable)

Details of any indemnity or option arrangement, or any agreement or understanding,formal or informal, relating to relevant securities which may be an inducement to dealor refrain from dealing entered into by the exempt principal trader making thedisclosure and any party to the offer or any person acting in concert witha party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state "none"

None

Details of any agreement, arrangement or understanding, formal or informal, betweenthe exempt principal trader making the disclosure and any other person relating to:(i) the voting rights of any relevant securities under any option; or(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

10 October 2018

Contact name:

Damian Flanagan

Telephone number:

+44 (28) 9040-9676