Form 8.3 PURETECH HEALTH PLC

FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR

MORE

Rule 8.3 of the Takeover Code (the "Code")

1.

KEY INFORMATION

(a)

Full name of discloser:

Barclays PLC.

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

PURETECH HEALTH PLC

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

07 Apr 2025

(f)

In addition to the company in 1(c) above, is the discloser making

NO

disclosures in respect of any other party to the offer?

2.

POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a)

Interests and short positions in the relevant securities of the offeror or offeree

to which the disclosure relates following the dealing(if any)

Class of relevant security:

1p ordinary

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

2,055,002

0.86%

1,895,300

0.79%

(2)

Cash-settled derivatives:

and/or controlled:

1,818,046

0.76%

1,936,662

0.81%

(3)

Stock-settled derivatives (including options)

and agreements to purchase/sell:

0

0.00%

0

0.00%

TOTAL:

3,873,048

1.61%

3,831,962

1.60%

(b)

Rights to subscribe for new securities (including directors and other executive

options)

Class of relevant security in relation to

which subscription right exists

Details, including nature of the rights

concerned and relevant percentages:

3.

DEALINGS (IF ANY) BY THE EXEMPT PRINCIPAL TRADER

(a)

Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

1p ordinary

Purchase

55,239

1.2453 GBP

1p ordinary

Purchase

39,171

1.2820 GBP

1p ordinary

Purchase

39,118

1.3820 GBP

1p ordinary

Purchase

38,656

1.3484 GBP

1p ordinary

Purchase

22,899

1.3012 GBP

1p ordinary

Purchase

21,041

1.2146 GBP

1p ordinary

Purchase

20,000

1.2325 GBP

1p ordinary

Purchase

8,954

1.2489 GBP

1p ordinary

Purchase

8,804

1.2807 GBP

1p ordinary

Purchase

6,713

1.2395 GBP

1p ordinary

Purchase

6,250

1.2250 GBP

1p ordinary

Purchase

6,239

1.2457 GBP

1p ordinary

Purchase

4,719

1.1977 GBP

ADR

Purchase

3,020

18.4341 USD

1p ordinary

Purchase

2,784

1.2370 GBP

1p ordinary

Purchase

2,317

1.2900 GBP

1p ordinary

Purchase

1,931

1.2940 GBP

1p ordinary

Purchase

1,692

1.2775 GBP

1p ordinary

Purchase

1,478

1.2042 GBP

ADR

Purchase

760

17.3300 USD

1p ordinary

Purchase

643

1.2475 GBP

1p ordinary

Purchase

631

1.2520 GBP

1p ordinary

Purchase

531

1.3070 GBP

ADR

Purchase

150

19.7650 USD

1p ordinary

Sale

114,965

1.3179 GBP

1p ordinary

Sale

105,077

1.3268 GBP

1p ordinary

Sale

66,748

1.2341 GBP

1p ordinary

Sale

62,235

1.2741 GBP

1p ordinary

Sale

40,088

1.2591 GBP

1p ordinary

Sale

38,028

1.3819 GBP

1p ordinary

Sale

34,989

1.2727 GBP

1p ordinary

Sale

29,900

1.2790 GBP

1p ordinary

Sale

14,154

1.3069 GBP

1p ordinary

Sale

12,110

1.2651 GBP

1p ordinary

Sale

9,652

1.3041 GBP

1p ordinary

Sale

9,500

1.2931 GBP

1p ordinary

Sale

8,889

1.3072 GBP

1p ordinary

Sale

8,804

1.2807 GBP

1p ordinary

Sale

6,848

1.3059 GBP

1p ordinary

Sale

5,633

1.2684 GBP

ADR

Sale

1,510

18.4341 USD

1p ordinary

Sale

1,040

1.3065 GBP

ADR

Sale

910

17.7313 USD

ADR

Sale

760

17.3300 USD

1p ordinary

Sale

676

1.2265 GBP

ADR

Sale

600

19.5000 USD

1p ordinary

Sale

380

1.2285 GBP

1p ordinary

Sale

291

1.2328 GBP

1p ordinary

Sale

166

1.2820 GBP

ADR

Sale

150

19.7650 USD

1p ordinary

Sale

126

1.2420 GBP

1p ordinary

Sale

1

1.2900 GBP

(b)

Cash-settled derivative transactions

Class of

Product

Nature of dealing

Number of

Price per

relevant

description

reference

unit

security

securities

1p ordinary

SWAP

Opening Long

2,030

1.2322 GBP

1p ordinary

SWAP

Increasing Long

2,335

1.2397 GBP

1p ordinary

SWAP

Increasing Long

729

1.2417 GBP

1p ordinary

SWAP

Increasing Long

382

1.2500 GBP

1p ordinary

SWAP

Increasing Long

2,141

1.2556 GBP

1p ordinary

SWAP

Increasing Long

6,778

1.2608 GBP

1p ordinary

SWAP

Increasing Long

5,633

1.2684 GBP

1p ordinary

SWAP

Increasing Long

34,989

1.2727 GBP

1p ordinary

SWAP

Increasing Long

53,316

1.2766 GBP

1p ordinary

SWAP

Increasing Long

29,900

1.2790 GBP

1p ordinary

SWAP

Increasing Long

1

1.2900 GBP

1p ordinary

SWAP

Increasing Long

1,040

1.3065 GBP

1p ordinary

SWAP

Increasing Long

121,324

1.3095 GBP

1p ordinary

SWAP

Increasing Long

38,477

1.3264 GBP

1p ordinary

SWAP

Increasing Long

22,782

1.3814 GBP

1p ordinary

SWAP

Increasing Long

38,028

1.3819 GBP

1p ordinary

SWAP

Increasing Long

18,575

1.3820 GBP

1p ordinary

SWAP

Decreasing Long

500

1.1940 GBP

1p ordinary

SWAP

Decreasing Long

4,219

1.1981 GBP

1p ordinary

SWAP

Decreasing Long

1,478

1.2042 GBP

1p ordinary

SWAP

Decreasing Long

58,968

1.2313 GBP

1p ordinary

SWAP

Decreasing Long

873

1.2390 GBP

1p ordinary

SWAP

Decreasing Long

643

1.2475 GBP

1p ordinary

SWAP

Decreasing Long

3,528

1.3820 GBP

1p ordinary

CFD

Opening Long

30,444

1.2320 GBP

1p ordinary

CFD

Increasing Long

191

1.2498 GBP

1p ordinary

CFD

Increasing Long

493

1.2618 GBP

1p ordinary

CFD

Increasing Long

166

1.2819 GBP

1p ordinary

CFD

Increasing Long

2,289

1.3820 GBP

1p ordinary

CFD

Opening Short

35,590

1.3820 GBP

(c)

Stock-settled derivative transactions (including options)

(i)

Writing, selling, purchasing or varying

Class

Product

Writing,

Number

Exercise

Type

Expiry

Option

of

description

purchasing,

of

price

date

money

relevant

selling,

securities

per unit

paid/

security

varying etc

to which

received

option

per unit

relates

(ii)

Exercising

Class of relevant

Product description

Exercising/ exercised against

Number of

Exercise price per

security

securities

unit

(d)

Other dealings (including subscribing for new securities)

Class of relevant

Nature of Dealings

Details

Price per unit (if

security

applicable)

4.

OTHER INFORMATION

(a)

Indemnity and other dealings arrangements

Details of any indemnity or option arrangement, or any agreement or understanding,

formal or informal, relating to relevant securities which may be an inducement to deal

or refrain from dealing entered into by the exempt principal trader making the disclosure and any party

to the offer or any person acting in concert with a party to the offer:

NONE

(b)

Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between

the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights of future acquisition or disposal of any relevant securities to which

any derivative is referenced:

NONE

(c)

Attachments

Is a Supplemental Form 8 (Open Positions) attached?

NO

Date of disclosure:

08 Apr 2025

Contact name:

Large Holdings Regulatory Operations

Telephone number:

020 3134 7213