Form 8 (OPD) Shire plc

FORM 8 (OPD) PUBLIC OPENING POSITION DISCLOSURE BY A PARTY TO AN OFFER Rules 8.1 and 8.2 of the Takeover Code (the "Code") 1. KEY INFORMATION (a) Identity of the party to the offer making Shire plcthe disclosure: (b) Owner or controller of interests and shortpositions disclosed, if different from 1(a): The naming of nominee or vehicle companies isinsufficient (c) Name of offeror/offeree in relation to Shire plcwhose relevant securities this form relates: Use a separate form for each party to the offer (d) Is the party to the offer making the OFFEREEdisclosure the offeror or the offeree? (e) Date position held: 2 July 2014 (f) Has the party previously disclosed, or is YESit today disclosing, under the Code in respectof any other party to this offer? If YES, specify which: AbbVie Inc. 2. POSITIONS OF THE PARTY TO THE OFFER MAKING THE DISCLOSURE (a) Interests and short positions in the relevant securities of the offeror orofferee to which the disclosure relates Class of relevant security: Shire 5p ordinary shares Interests Short positions Number % Number % (1) Relevant Nil 0.00 Nil 0.00securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: Nil 0.00 Nil 0.00 All interests and all short positions should be disclosed. Details of any open derivative or option positions, or agreements to purchaseor sell relevant securities, should be given on a Supplemental Form 8 (OpenPositions). Details of any securities borrowing and lending positions or financialcollateral arrangements should be disclosed on a Supplemental Form 8 (SBL). (b) Rights to subscribe for new securities Class of relevant security in relation Noneto which subscription right exists: Details, including nature of the Nonerights concerned and relevantpercentages: If there are positions or rights to subscribe to disclose in more than oneclass of relevant securities of the offeror or offeree named in 1(c), copytable 2(a) or (b) (as appropriate) for each additional class of relevantsecurity. (c) Irrevocable commitments and letters of intent Details of any irrevocable commitments or letters of intent procured by theparty to the offer making the disclosure or any person acting in concert withit (see Note 3 on Rule 2.11 of the Code): None 3. POSITIONS OF PERSONS ACTING IN CONCERT WITH THE PARTY TO THE OFFER MAKINGTHE DISCLOSURE Details of any interests, short positions and rights to subscribe of any personacting in concert with the party to the offer making the disclosure: 3(a) Shares held by directors of Shire plc Director Number of Shire 5p ordinary shares Percentage of existing issued shares Dr. Flemming Ornskov 22,000 0.00 Dominic Blakemore 248 0.00 William Burns 1,268 0.00 Dr. Steven Gillis 1,206 (402 ADS)* 0.00 Dr. David Ginsburg 1,155 (385 ADS)* 0.00 David Kappler 11,322 0.00 Susan Kilsby 1,323 (441 ADS)* 0.00 Anne Minto 3,511 0.00 David Stout 1,209 (403 ADS)* 0.00 * Shares held in the form of American Depository Shares ("ADS"). 1 ADS isequivalent to 3 x 5p ordinary shares. 3(b) Directors rights to subscribe in Shire plc shares Portfolio Share Plan - Award date: 28/2/2013 Director Award type Number of Shire 5p ordinary Vesting date shares Dr. Flemming Stock 136,803 (45,601 ADS)* 28/2/2016 - 28/Ornskov Appreciation 2/2020 Right Dr. Flemming Performance 102,603 (34,201 ADS)* 28/2/2016Ornskov Share Award * Shares held in the form of American Depository Shares ("ADS"). 1 ADS isequivalent to 3 x 5p ordinary shares. Portfolio Share Plan - Award date: 2/5/2013 Director Award type Number of Shire 5p ordinary Vesting date shares Dr. Flemming Stock 56,952 (18,984 ADS)* 2/5/2016 - 2/5/Ornskov Appreciation 2020 Right Dr. Flemming Performance 32,463 (10,821 ADS)* 2/5/2016Ornskov Share Award * Shares held in the form of American Depository Shares ("ADS"). 1 ADS isequivalent to 3 x 5p ordinary shares. Portfolio Share Plan - Award date: 28/2/2014 Director Award type Number of Shire 5p ordinary Vesting date shares Dr. Flemming Stock 102,522 (34,174 ADS)* 28/2/2017 - 28/Ornskov Appreciation 2/2021 Right Dr. Flemming Performance 76,893 (25,631 ADS)* 28/2/2017Ornskov Share Award * Shares held in the form of American Depository Shares ("ADS"). 1 ADS isequivalent to 3 x 5p ordinary shares. Deferred share award - Award date: 2/5/2013 Director Award type Number of Shire 5p ordinary Vesting date shares Dr. Flemming Ornskov Deferred 45,858 (15,286 ADS)* 28/2/2015 Shares * Shares held in the form of American Depository Shares ("ADS"). 1 ADS isequivalent to 3 x 5p ordinary shares. Executive Annual Incentive Plan - Award date: 31/3/2014 Director Award type Number of Shire 5p ordinary Vesting date shares Dr. Flemming Ornskov Deferred 8,109 (2,703 ADS)* 31/3/2017 Shares * Shares held in the form of American Depository Shares ("ADS"). 1 ADS isequivalent to 3 x 5p ordinary shares. Employee Stock Purchase Plan Director Product Option price Number of Shire Exercise description shares date Dr. Flemming Option over The option On 1/11/2013, the 31/10/2014Ornskov ADS price is the option over ADS was lower of 85% granted. Dr. Ornskov of the fair elected to save USD market value 480.76 per fortnight of an ADS on (such that an amount 1/11/2013 and of USD 12,499.76 85% of the will have been saved fair market by the exercise value of an date). ADS on the exercise If the fair market date. value of an ADS on 1 /11/2013 applies (being USD 134.04), then the option price will be USD 113.93 (85% of USD 134.04) which would in turn mean that Dr. Ornskov will receive 109 ADS (=327 shares). 3(c) Share interests of connected advisers Citigroup Global Markets Inc Class of relevant security: 5p ordinary shares (held through ADS) Interests Short positions Number % Number % (1) Relevant Nil 0.00 55,473 0.01securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: Nil 0.00 55,473 0.01 Citibank NA Class of relevant security: 5p ordinary shares (held through ADS) Interests Short positions Number % Number % (1) Relevant 6,816 0.00 Nil 0.00securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: 6,816 0.00 Nil 0.00 Citigroup Derivatives Markets Inc Class of relevant security: 5p ordinary shares (held through ADS) Interests Short positions Number % Number % (1) Relevant 78,417 0.01 89,355 0.02securities owned and/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and 752,700 0.13 855,600 0.15agreements topurchase/sell: TOTAL: 831,117 0.14 944,955 0.16 (GS) GOLDMAN SACHS FINANCIAL MARKETS, L.P. Class of relevant security: 5p ordinary shares (held directly or through AD S) Interests Short positions Number % Number % (1) Relevant 12 0.00 Nil 0.00securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: 12 0.00 Nil 0.00 (GS) GOLDMAN, SACHS & CO. Class of relevant security: 5p ordinary shares (held directly or through ADS) Interests Short positions Number % Number % (1) Relevant securities owned 270,328 0.05 64,980 0.01and/or controlled: (2) Derivatives (other than Nil 0.00 Nil 0.00options): (3) Options and agreements to 57,300 0.01 44,700 0.01purchase/sell: TOTAL: 327,628 0.06 109,680 0.02 (GS) GOLDMAN SACHS BANK AG Class of relevant security: 5p ordinary shares (held directly or through ADS) Interests Short positions Number % Number % (1) Relevant 68,893 0.01 Nil 0.00securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: 68,893 0.01 Nil 0.00 Deutsche Bank Suisse SA Class of relevant security: 5p ordinary shares Interests Short positions Number % Number % (1) Relevant 690 0.00 Nil 0.00securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: 690 0.00 Nil 0.00 Oppenheim Asset Management Services S.a.r.l Class of relevant security: 5p ordinary shares Interests Short positions Number % Number % (1) Relevant 10,694 0.00 Nil 0.00securities ownedand/or controlled: (2) Derivatives Nil 0.00 Nil 0.00(other thanoptions): (3) Options and Nil 0.00 Nil 0.00agreements topurchase/sell: TOTAL: 10,694 0.00 Nil 0.00 If there are positions or rights to subscribe to disclose in more than oneclass of relevant securities of the offeror or offeree named in 1(c), copytable 3 for each additional class of relevant security. Details of any open derivative or option positions, or agreements to purchaseor sell relevant securities, should be given on a Supplemental Form 8 (OpenPositions). Details of any securities borrowing and lending positions or financialcollateral arrangements should be disclosed on a Supplemental Form 8 (SBL). 4. OTHER INFORMATION (a) Indemnity and other dealing arrangements Details of any indemnity or option arrangement, or any agreement orunderstanding, formal or informal, relating to relevant securities which may bean inducement to deal or refrain from dealing entered into by the party to theoffer making the disclosure or any person acting in concert with it: If there are no such agreements, arrangements or understandings, state "none" None (b) Agreements, arrangements or understandings relating to options orderivatives Details of any agreement, arrangement or understanding, formal or informal,between the party to the offer making the disclosure, or any person acting inconcert with it, and any other person relating to: (i) the voting rights of any relevant securities under any option; or (ii) the voting rights or future acquisition or disposal of any relevantsecurities to which any derivative is referenced: If there are no such agreements, arrangements or understandings, state "none" None (c) Attachments Are any Supplemental Forms attached? Supplemental Form 8 (Open Positions) YES Supplemental Form 8 (SBL) YES Date of disclosure: 3 July 2014 Contact name: Tatjana May (General Counsel and Company Secretary) Tony Guthrie (Deputy Company Secretary) Telephone number: +44 1256 894 000 Public disclosures under Rule 8 of the Code must be made to a RegulatoryInformation Service and must also be emailed to the Takeover Panel [email protected]. The Panel's Market Surveillance Unit is availablefor consultation in relation to the Code's dealing disclosure requirements on+44 (0)20 7638 0129. The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk. SUPPLEMENTAL FORM 8 (OPEN POSITIONS) DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC. Note 5(i) on Rule 8 of the Takeover Code (the "Code") 1. KEY INFORMATION Identity of person whose open positions are Citigroup Derivatives Marketsbeing disclosed: Inc Name of offeror/offeree in relation to whose Shire Plcrelevant securities the disclosure relates: 2. OPTIONS AND DERIVATIVES Class of Product Written or Number of Exercise Type Expiry date relevant description purchased securities price per security e.g. call to which unit e.g. option option or American, derivative European relates etc. ADS Put Option Purchased 323 200 European 2014-07-19 ADS Call Option Purchased 184 260 European 2014-10-18 ADS Put Option Purchased 166 210 European 2014-07-19 ADS Put Option Purchased 157 200 European 2014-07-19 ADS Call Option Purchased 136 260 European 2014-10-18 ADS Call Option Purchased 125 260 European 2014-08-16 ADS Call Option Purchased 120 260 European 2014-10-18 ADS Call Option Purchased 109 255 European 2014-07-19 ADS Call Option Purchased 80 255 European 2014-07-19 ADS Call Option Purchased 73 260 European 2014-07-19 ADS Put Option Purchased 60 200 European 2014-07-19 ADS Call Option Purchased 52 250 European 2014-07-19 ADS Call Option Purchased 50 260 European 2014-08-16 ADS Call Option Purchased 45 190 European 2014-07-19 ADS Call Option Purchased 43 180 European 2014-07-19 ADS Call Option Purchased 41 260 European 2014-07-19 ADS Call Option Purchased 40 195 European 2014-10-18 ADS Call Option Purchased 39 250 European 2014-07-19 ADS Call Option Purchased 38 190 European 2014-07-19 ADS Call Option Purchased 36 250 European 2014-08-16 ADS Call Option Purchased 36 200 European 2014-10-18 ADS Call Option Purchased 33 260 European 2014-07-19 ADS Put Option Purchased 32 165 European 2014-07-19 ADS Put Option Purchased 30 270 European 2014-08-16 ADS Put Option Purchased 28 205 European 2014-07-19 ADS Put Option Purchased 28 210 European 2014-07-19 ADS Put Option Purchased 26 210 European 2014-07-19 ADS Call Option Purchased 25 185 European 2014-07-19 ADS Call Option Purchased 25 250 European 2014-08-16 ADS Put Option Purchased 23 160 European 2014-07-19 ADS Put Option Purchased 22 165 European 2014-10-18 ADS Call Option Purchased 20 215 European 2014-07-19 ADS Call Option Purchased 20 155 European 2014-10-18 ADS Call Option Purchased 20 170 European 2014-10-18 ADS Call Option Purchased 20 220 European 2014-10-18 ADS Call Option Purchased 19 185 European 2014-07-19 ADS Call Option Purchased 18 180 European 2014-07-19 ADS Put Option Purchased 16 130 European 2014-07-19 ADS Call Option Purchased 16 180 European 2014-07-19 ADS Call Option Purchased 16 190 European 2014-07-19 ADS Put Option Purchased 16 195 European 2014-07-19 ADS Put Option Purchased 16 205 European 2014-07-19 ADS Call Option Purchased 16 250 European 2014-07-19 ADS Call Option Purchased 16 200 European 2014-10-18 ADS Call Option Purchased 15 145 European 2014-07-19 ADS Call Option Purchased 15 260 European 2014-07-19 ADS Put Option Purchased 15 90 European 2014-07-19 ADS Put Option Purchased 15 165 European 2014-10-18 ADS Call Option Purchased 14 200 European 2014-07-19 ADS Call Option Purchased 13 200 European 2015-01-17 ADS Put Option Purchased 13 185 European 2014-07-19 ADS Put Option Purchased 13 210 European 2014-07-19 ADS Put Option Purchased 13 210 European 2014-07-19 ADS Call Option Purchased 13 230 European 2014-07-19 ADS Put Option Purchased 13 85 European 2014-10-18 ADS Call Option Purchased 12 170 European 2014-07-19 ADS Put Option Purchased 12 170 European 2014-07-19 ADS Put Option Purchased 12 175 European 2014-07-19 ADS Call Option Purchased 12 190 European 2014-10-18 ADS Put Option Purchased 12 265 European 2014-10-18 ADS Put Option Purchased 11 185 European 2015-01-17 ADS Put Option Purchased 11 140 European 2014-07-19 ADS Put Option Purchased 11 175 European 2014-07-19 ADS Call Option Purchased 11 220 European 2014-07-19 ADS Put Option Purchased 10 120 European 2014-07-19 ADS Call Option Purchased 10 170 European 2014-07-19 ADS Put Option Purchased 10 170 European 2014-07-19 ADS Call Option Purchased 10 185 European 2014-07-19 ADS Call Option Purchased 10 215 European 2014-08-16 ADS Call Option Purchased 10 220 European 2014-08-16 ADS Put Option Purchased 10 220 European 2014-08-16 ADS Put Option Purchased 10 255 European 2014-08-16 ADS Put Option Purchased 10 260 European 2014-08-16 ADS Put Option Purchased 10 140 European 2014-10-18 ADS Call Option Purchased 10 250 European 2014-10-18 ADS Put Option Purchased 9 115 European 2014-07-19 ADS Call Option Purchased 9 195 European 2014-07-19 ADS Put Option Purchased 9 220 European 2014-07-19 ADS Call Option Purchased 8 220 European 2015-01-17 ADS Call Option Purchased 8 280 European 2015-01-17 ADS Put Option Purchased 8 155 European 2014-07-19 ADS Put Option Purchased 8 215 European 2014-07-19 ADS Put Option Purchased 8 220 European 2014-07-19 ADS Put Option Purchased 8 85 European 2014-07-19 ADS Put Option Purchased 8 175 European 2014-10-18 ADS Call Option Purchased 7 250 European 2015-01-17 ADS Put Option Purchased 7 175 European 2014-07-19 ADS Put Option Purchased 7 185 European 2014-07-19 ADS Put Option Purchased 7 185 European 2014-07-19 ADS Put Option Purchased 7 205 European 2014-07-19 ADS Call Option Purchased 7 220 European 2014-07-19 ADS Call Option Purchased 7 175 European 2014-10-18 ADS Call Option Purchased 7 175 European 2014-10-18 ADS Put Option Purchased 7 175 European 2014-10-18 ADS Put Option Purchased 7 180 European 2014-10-18 ADS Call Option Purchased 6 250 European 2015-01-17 ADS Put Option Purchased 6 110 European 2014-07-19 ADS Call Option Purchased 6 185 European 2014-07-19 ADS Put Option Purchased 6 205 European 2014-07-19 ADS Call Option Purchased 6 210 European 2014-07-19 ADS Call Option Purchased 6 240 European 2014-08-16 ADS Put Option Purchased 6 105 European 2014-10-18 ADS Put Option Purchased 6 170 European 2014-10-18 ADS Call Option Purchased 6 175 European 2014-10-18 ADS Put Option Purchased 6 175 European 2014-10-18 ADS Put Option Purchased 6 180 European 2014-10-18 ADS Put Option Purchased 5 105 European 2014-07-19 ADS Put Option Purchased 5 160 European 2014-07-19 ADS Put Option Purchased 5 195 European 2014-07-19 ADS Put Option Purchased 5 215 European 2014-07-19 ADS Put Option Purchased 5 85 European 2014-07-19 ADS Put Option Purchased 5 195 European 2014-08-16 ADS Call Option Purchased 5 245 European 2014-08-16 ADS Call Option Purchased 5 270 European 2014-08-16 ADS Call Option Purchased 5 165 European 2014-10-18 ADS Put Option Purchased 5 165 European 2014-10-18 ADS Call Option Purchased 4 265 European 2015-01-17 ADS Call Option Purchased 4 270 European 2015-01-17 ADS Put Option Purchased 4 100 European 2014-07-19 ADS Put Option Purchased 4 135 European 2014-07-19 ADS Put Option Purchased 4 160 European 2014-07-19 ADS Put Option Purchased 4 160 European 2014-07-19 ADS Put Option Purchased 4 170 European 2014-07-19 ADS Call Option Purchased 4 175 European 2014-07-19 ADS Call Option Purchased 4 180 European 2014-07-19 ADS Put Option Purchased 4 200 European 2014-07-19 ADS Call Option Purchased 4 210 European 2014-07-19 ADS Put Option Purchased 4 220 European 2014-07-19 ADS Call Option Purchased 4 255 European 2014-07-19 ADS Put Option Purchased 4 195 European 2014-08-16 ADS Put Option Purchased 4 225 European 2014-08-16 ADS Call Option Purchased 4 160 European 2014-10-18 ADS Put Option Purchased 4 170 European 2014-10-18 ADS Put Option Purchased 4 180 European 2014-10-18 ADS Put Option Purchased 3 125 European 2014-07-19 ADS Put Option Purchased 3 135 European 2014-07-19 ADS Put Option Purchased 3 140 European 2014-07-19 ADS Call Option Purchased 3 155 European 2014-07-19 ADS Call Option Purchased 3 170 European 2014-07-19 ADS Put Option Purchased 3 185 European 2014-07-19 ADS Call Option Purchased 3 195 European 2014-07-19 ADS Put Option Purchased 3 200 European 2014-07-19 ADS Put Option Purchased 3 225 European 2014-07-19 ADS Put Option Purchased 3 230 European 2014-07-19 ADS Call Option Purchased 3 265 European 2014-08-16 ADS Call Option Purchased 3 270 European 2014-08-16 ADS Call Option Purchased 3 270 European 2014-08-16 ADS Put Option Purchased 3 170 European 2014-10-18 ADS Call Option Purchased 3 185 European 2014-10-18 ADS Put Option Purchased 3 200 European 2014-10-18 ADS Put Option Purchased 3 200 European 2014-10-18 ADS Call Option Purchased 3 220 European 2014-10-18 ADS Put Option Purchased 2 120 European 2015-01-17 ADS Put Option Purchased 2 140 European 2015-01-17 ADS Put Option Purchased 2 150 European 2015-01-17 ADS Put Option Purchased 2 175 European 2015-01-17 ADS Put Option Purchased 2 185 European 2015-01-17 ADS Call Option Purchased 2 190 European 2015-01-17 ADS Put Option Purchased 2 195 European 2015-01-17 ADS Put Option Purchased 2 200 European 2015-01-17 ADS Call Option Purchased 2 250 European 2015-01-17 ADS Call Option Purchased 2 265 European 2015-01-17 ADS Call Option Purchased 2 265 European 2015-01-17 ADS Call Option Purchased 2 125 European 2014-07-19 ADS Put Option Purchased 2 140 European 2014-07-19 ADS Call Option Purchased 2 145 European 2014-07-19 ADS Put Option Purchased 2 145 European 2014-07-19 ADS Put Option Purchased 2 160 European 2014-07-19 ADS Put Option Purchased 2 170 European 2014-07-19 ADS Call Option Purchased 2 175 European 2014-07-19 ADS Call Option Purchased 2 185 European 2014-07-19 ADS Put Option Purchased 2 185 European 2014-07-19 ADS Call Option Purchased 2 220 European 2014-07-19 ADS Put Option Purchased 2 225 European 2014-07-19 ADS Call Option Purchased 2 150 European 2014-10-18 ADS Call Option Purchased 2 160 European 2014-10-18 ADS Call Option Purchased 2 170 European 2014-10-18 ADS Call Option Purchased 2 170 European 2014-10-18 ADS Put Option Purchased 2 170 European 2014-10-18 ADS Call Option Purchased 2 175 European 2014-10-18 ADS Call Option Purchased 2 180 European 2014-10-18 ADS Put Option Purchased 2 185 European 2014-10-18 ADS Put Option Purchased 2 195 European 2014-10-18 ADS Put Option Purchased 2 195 European 2014-10-18 ADS Put Option Purchased 2 195 European 2014-10-18 ADS Put Option Purchased 2 200 European 2014-10-18 ADS Put Option Purchased 2 200 European 2014-10-18 ADS Call Option Purchased 2 210 European 2014-10-18 ADS Put Option Purchased 2 260 European 2014-10-18 ADS Call Option Purchased 2 265 European 2014-10-18 ADS Call Option Purchased 2 275 European 2014-10-18 ADS Put Option Purchased 1 170 European 2015-01-17 ADS Call Option Purchased 1 180 European 2015-01-17 ADS Call Option Purchased 1 190 European 2015-01-17 ADS Call Option Purchased 1 200 European 2015-01-17 ADS Call Option Purchased 1 200 European 2015-01-17 ADS Call Option Purchased 1 250 European 2015-01-17 ADS Call Option Purchased 1 265 European 2015-01-17 ADS Call Option Purchased 1 275 European 2015-01-17 ADS Put Option Purchased 1 130 European 2014-07-19 ADS Put Option Purchased 1 145 European 2014-07-19 ADS Put Option Purchased 1 150 European 2014-07-19 ADS Put Option Purchased 1 150 European 2014-07-19 ADS Put Option Purchased 1 150 European 2014-07-19 ADS Put Option Purchased 1 150 European 2014-07-19 ADS Call Option Purchased 1 160 European 2014-07-19 ADS Call Option Purchased 1 165 European 2014-07-19 ADS Call Option Purchased 1 165 European 2014-07-19 ADS Put Option Purchased 1 165 European 2014-07-19 ADS Put Option Purchased 1 165 European 2014-07-19 ADS Call Option Purchased 1 170 European 2014-07-19 ADS Put Option Purchased 1 170 European 2014-07-19 ADS Put Option Purchased 1 170 European 2014-07-19 ADS Put Option Purchased 1 175 European 2014-07-19 ADS Put Option Purchased 1 180 European 2014-07-19 ADS Put Option Purchased 1 180 European 2014-07-19 ADS Put Option Purchased 1 185 European 2014-07-19 ADS Put Option Purchased 1 215 European 2014-07-19 ADS Call Option Purchased 1 220 European 2014-07-19 ADS Call Option Purchased 1 230 European 2014-07-19 ADS Call Option Purchased 1 260 European 2014-07-19 ADS Put Option Purchased 1 85 European 2014-07-19 ADS Put Option Purchased 1 210 European 2014-08-16 ADS Put Option Purchased 1 225 European 2014-08-16 ADS Call Option Purchased 1 230 European 2014-08-16 ADS Call Option Purchased 1 240 European 2014-08-16 ADS Call Option Purchased 1 270 European 2014-08-16 ADS Call Option Purchased 1 270 European 2014-08-16 ADS Call Option Purchased 1 275 European 2014-08-16 ADS Put Option Purchased 1 140 European 2014-10-18 ADS Call Option Purchased 1 145 European 2014-10-18 ADS Call Option Purchased 1 165 European 2014-10-18 ADS Put Option Purchased 1 175 European 2014-10-18 ADS Put Option Purchased 1 175 European 2014-10-18 ADS Call Option Purchased 1 180 European 2014-10-18 ADS Call Option Purchased 1 185 European 2014-10-18 ADS Call Option Purchased 1 190 European 2014-10-18 ADS Put Option Purchased 1 190 European 2014-10-18 ADS Put Option Purchased 1 190 European 2014-10-18 ADS Put Option Purchased 1 190 European 2014-10-18 ADS Call Option Purchased 1 200 European 2014-10-18 ADS Put Option Purchased 1 200 European 2014-10-18 ADS Call Option Purchased 1 220 European 2014-10-18 ADS Call Option Purchased 1 220 European 2014-10-18 ADS Call Option Purchased 1 220 European 2014-10-18 ADS Call Option Purchased 1 220 European 2014-10-18 ADS Put Option Purchased 1 260 European 2014-10-18 ADS Put Option Purchased 1 260 European 2014-10-18 ADS Put Option Purchased 1 260 European 2014-10-18 ADS Call Option Purchased 1 265 European 2014-10-18 ADS Call Option Purchased 1 265 European 2014-10-18 ADS Call Option Purchased 1 265 European 2014-10-18 ADS Call Option Purchased 1 275 European 2014-10-18 ADS Call Option Purchased 1 275 European 2014-10-18 ADS Call Option Purchased 1 275 European 2014-10-18 ADS Call Option Written -1 100 European 2015-01-17 ADS Call Option Written -1 110 European 2015-01-17 ADS Call Option Written -1 110 European 2015-01-17 ADS Call Option Written -1 120 European 2015-01-17 ADS Call Option Written -1 135 European 2015-01-17 ADS Call Option Written -1 135 European 2015-01-17 ADS Call Option Written -1 175 European 2015-01-17 ADS Call Option Written -1 235 European 2015-01-17 ADS Call Option Written -1 240 European 2015-01-17 ADS Call Option Written -1 240 European 2015-01-17 ADS Call Option Written -1 240 European 2015-01-17 ADS Call Option Written -1 125 European 2014-07-19 ADS Call Option Written -1 125 European 2014-07-19 ADS Call Option Written -1 125 European 2014-07-19 ADS Put Option Written -1 150 European 2014-07-19 ADS Call Option Written -1 160 European 2014-07-19 ADS Call Option Written -1 160 European 2014-07-19 ADS Call Option Written -1 160 European 2014-07-19 ADS Put Option Written -1 165 European 2014-07-19 ADS Call Option Written -1 180 European 2014-07-19 ADS Call Option Written -1 190 European 2014-07-19 ADS Put Option Written -1 190 European 2014-07-19 ADS Put Option Written -1 190 European 2014-07-19 ADS Call Option Written -1 195 European 2014-07-19 ADS Call Option Written -1 200 European 2014-07-19 ADS Put Option Written -1 235 European 2014-07-19 ADS Put Option Written -1 200 European 2014-08-16 ADS Call Option Written -1 220 European 2014-08-16 ADS Put Option Written -1 220 European 2014-08-16 ADS Put Option Written -1 145 European 2014-10-18 ADS Put Option Written -1 150 European 2014-10-18 ADS Call Option Written -1 155 European 2014-10-18 ADS Put Option Written -1 155 European 2014-10-18 ADS Call Option Written -1 170 European 2014-10-18 ADS Put Option Written -1 185 European 2014-10-18 ADS Put Option Written -1 185 European 2014-10-18 ADS Put Option Written -1 185 European 2014-10-18 ADS Put Option Written -1 185 European 2014-10-18 ADS Call Option Written -2 130 European 2015-01-17 ADS Call Option Written -2 135 European 2015-01-17 ADS Call Option Written -2 235 European 2015-01-17 ADS Call Option Written -2 240 European 2015-01-17 ADS Call Option Written -2 155 European 2014-07-19 ADS Put Option Written -2 190 European 2014-07-19 ADS Call Option Written -2 245 European 2014-07-19 ADS Call Option Written -2 225 European 2014-08-16 ADS Call Option Written -2 225 European 2014-08-16 ADS Call Option Written -2 225 European 2014-08-16 ADS Put Option Written -2 100 European 2014-10-18 ADS Put Option Written -2 130 European 2014-10-18 ADS Put Option Written -2 150 European 2014-10-18 ADS Call Option Written -2 165 European 2014-10-18 ADS Call Option Written -2 190 European 2014-10-18 ADS Call Option Written -3 210 European 2015-01-17 ADS Call Option Written -3 220 European 2015-01-17 ADS Call Option Written -3 150 European 2014-07-19 ADS Put Option Written -3 180 European 2014-07-19 ADS Call Option Written -3 190 European 2014-07-19 ADS Put Option Written -3 230 European 2014-08-16 ADS Call Option Written -3 235 European 2014-08-16 ADS Put Option Written -3 150 European 2014-10-18 ADS Call Option Written -3 230 European 2014-10-18 ADS Put Option Written -3 90 European 2014-10-18 ADS Put Option Written -4 160 European 2015-01-17 ADS Put Option Written -4 100 European 2014-07-19 ADS Call Option Written -4 125 European 2014-07-19 ADS Put Option Written -4 135 European 2014-07-19 ADS Put Option Written -4 225 European 2014-08-16 ADS Put Option Written -4 230 European 2014-08-16 ADS Call Option Written -4 235 European 2014-08-16 ADS Put Option Written -4 145 European 2014-10-18 ADS Put Option Written -4 170 European 2014-10-18 ADS Call Option Written -4 240 European 2014-10-18 ADS Put Option Written -5 180 European 2014-07-19 ADS Call Option Written -5 245 European 2014-07-19 ADS Put Option Written -5 175 European 2014-08-16 ADS Call Option Written -5 235 European 2014-08-16 ADS Call Option Written -5 290 European 2014-08-16 ADS Put Option Written -6 200 European 2014-07-19 ADS Put Option Written -6 230 European 2014-07-19 ADS Call Option Written -6 245 European 2014-07-19 ADS Call Option Written -6 230 European 2014-08-16 ADS Call Option Written -6 240 European 2014-08-16 ADS Call Option Written -6 250 European 2014-08-16 ADS Call Option Written -6 240 European 2014-10-18 ADS Put Option Written -7 215 European 2014-07-19 ADS Call Option Written -7 270 European 2014-07-19 ADS Call Option Written -8 210 European 2015-01-17 ADS Put Option Written -8 190 European 2014-07-19 ADS Put Option Written -8 215 European 2014-07-19 ADS Call Option Written -8 235 European 2014-07-19 ADS Put Option Written -8 115 European 2014-10-18 ADS Put Option Written -10 90 European 2015-01-17 ADS Put Option Written -10 95 European 2015-01-17 ADS Put Option Written -10 205 European 2014-07-19 ADS Call Option Written -10 230 European 2014-07-19 ADS Call Option Written -10 240 European 2014-07-19 ADS Call Option Written -10 265 European 2014-07-19 ADS Call Option Written -10 295 European 2014-07-19 ADS Put Option Written -10 130 European 2014-10-18 ADS Call Option Written -10 185 European 2014-10-18 ADS Call Option Written -10 185 European 2014-10-18 ADS Put Option Written -10 230 European 2014-10-18 ADS Call Option Written -11 155 European 2014-07-19 ADS Call Option Written -11 160 European 2014-10-18 ADS Put Option Written -11 95 European 2014-10-18 ADS Call Option Written -12 195 European 2014-07-19 ADS Call Option Written -15 170 European 2014-07-19 ADS Call Option Written -16 165 European 2014-07-19 ADS Call Option Written -16 235 European 2014-07-19 ADS Put Option Written -17 150 European 2014-07-19 ADS Call Option Written -17 240 European 2014-07-19 ADS Put Option Written -19 115 European 2014-10-18 ADS Call Option Written -20 200 European 2014-07-19 ADS Call Option Written -20 270 European 2014-07-19 ADS Call Option Written -20 300 European 2014-07-19 ADS Call Option Written -21 270 European 2014-07-19 ADS Put Option Written -21 120 European 2014-10-18 ADS Put Option Written -22 230 European 2014-07-19 ADS Call Option Written -22 245 European 2014-07-19 ADS Call Option Written -23 200 European 2014-07-19 ADS Call Option Written -24 240 European 2014-07-19 ADS Call Option Written -25 165 European 2014-07-19 ADS Call Option Written -26 230 European 2014-08-16 ADS Call Option Written -27 195 European 2014-07-19 ADS Call Option Written -27 230 European 2014-07-19 ADS Put Option Written -30 105 European 2015-01-17 ADS Call Option Written -30 300 European 2014-07-19 ADS Call Option Written -31 295 European 2014-07-19 ADS Call Option Written -36 240 European 2014-07-19 ADS Call Option Written -38 170 European 2014-07-19 ADS Call Option Written -45 190 European 2014-07-19 ADS Call Option Written -46 230 European 2014-07-19 ADS Call Option Written -55 270 European 2014-07-19 ADS Call Option Written -55 240 European 2014-10-18 ADS Call Option Written -64 250 European 2014-07-19 ADS Call Option Written -65 240 European 2014-10-18 ADS Call Option Written -75 240 European 2014-07-19 ADS Call Option Written -81 240 European 2014-10-18 ADS Call Option Written -93 235 European 2014-07-19 ADS Call Option Written -111 230 European 2014-08-16 ADS Put Option Written -147 195 European 2014-07-19 ADS Put Option Written -190 195 European 2014-07-19 3. AGREEMENTS TO PURCHASE OR SELL ETC. Full details should be given so that the nature of the interest or position canbe fully understood: None It is not necessary to provide details on a Supplemental Form (Open Positions)with regard to contracts for differences ("CFDs") or spread bets. The currency of all prices and other monetary amounts should be stated. The Panel's Market Surveillance Unit is available for consultation in relationto the Code's dealing disclosure requirements on +44 (0)20 7638 0129. The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk . SUPPLEMENTAL FORM 8 (SBL) DETAILS OF SECURITIES BORROWING AND LENDING AND FINANCIAL COLLATERAL ARRANGEMENTS BY PARTIES TO AN OFFER AND PERSONS ACTING IN CONCERT Note 5(l) on Rule 8 of the Takeover Code (the "Code") 1. KEY INFORMATION Identity of person whose positions/transactions (GS) GOLDMAN SACHS FINANCIALare being disclosed: MARKETS, L.P. Name of offeror/offeree in relation to whose SHIRE PLCrelevant securities this form relates: 2. SECURITIES BORROWING AND LENDING/FINANCIAL COLLATERAL POSITIONS Class of relevant security: 5p ordinary shares and ADS Number % Securities borrowed: 0 0.00 Securities lent (including securities subject 12 0.00to a security financial collateral arrangementwith right of use or a title transfercollateral arrangement): Details of borrowed relevant securities which have been either on-lent or solddo not need to be disclosed. 3. SECURITIES BORROWING AND LENDING/FINANCIAL COLLATERAL TRANSACTIONS Class of relevant Nature of transaction Number of security securities e.g. securities lending/borrowing, delivery/ receipt of recalled securities, entering into financial collateral arrangement with right of use, entering into title transfer collateral arrangement etc. The Panel's Market Surveillance Unit is available for consultation in relationto the Code's dealing disclosure requirements on +44 (0)20 7638 0129. The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk . SUPPLEMENTAL FORM 8 (OPEN POSITIONS) DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENT TO PURCHASE OR SELL ETC. Note 5(i) on Rule 8 of the Takeover Code (the "Code") 1. KEY INFORMATION Identity of the person whose open positions are (GS) GOLDMAN, SACHS & CO.being disclosed: Name of offeror/offeree in relation to whose SHIRE PLCrelevant securities disclosure relates: 2. OPTIONS AND DERIVATIVES Class of Product Written or Number of Exercise Type Expiry relevant description purchased securities price per date security e.g. call to which unit e.g. option option or American, derivative European relates etc. 5p ordinary Call Option Purchased 300 140.0000 AMER 18/10/ USD 2014 5p ordinary Call Option Sold 300 160.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 300 180.0000 AMER 17/01/ USD 2015 5p ordinary Call Option Sold 300 210.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 300 240.0000 AMER 17/01/ USD 2015 5p ordinary Call Option Purchased 300 270.0000 AMER 17/01/ USD 2015 5p ordinary Call Option Purchased 600 125.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 600 145.0000 AMER 18/10/ USD 2014 5p ordinary Call Option Sold 600 165.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 600 180.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 900 175.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Sold 1,200 140.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 1,500 200.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 1,500 240.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 1,800 170.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 1,800 195.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Sold 1,800 230.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Sold 900 150.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Sold 2,400 190.0000 AMER 18/10/ USD 2014 5p ordinary Call Option Sold 2,400 220.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 3,600 250.0000 AMER 17/01/ USD 2015 5p ordinary Call Option Purchased 3,600 260.0000 AMER 17/01/ USD 2015 5p ordinary Call Option Sold 3,900 185.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 4,500 250.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Purchased 5,100 190.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Sold 8,100 260.0000 AMER 19/07/ USD 2014 5p ordinary Call Option Sold 12,300 175.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Sold 300 140.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 300 140.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Purchased 600 155.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Sold 600 175.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Sold 900 165.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 900 170.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Purchased 900 180.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 900 185.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 900 210.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Purchased 1,200 160.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Purchased 1,200 200.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 1,500 120.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 1,500 170.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Sold 1,800 125.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Purchased 2,100 135.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 2,100 145.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 3,000 150.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 3,000 190.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 3,300 220.0000 AMER 19/07/ USD 2014 5p ordinary Put Option Sold 3,900 150.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Purchased 4,500 110.0000 AMER 18/10/ USD 2014 5p ordinary Put Option Sold 5,100 175.0000 AMER 19/07/ USD 2014 3. AGREEMENTS TO PURCHASE OR SELL Full details should be given so that the nature of the interest or position canbe fully understood: It is not necessary to provide details on a Supplement form (Open Positions)with regard to contracts for differences ("CFD") or spread bets The currency of all pieces and other monetary amounts should be stated. The Panel's Market Surveillance Unit is available for consultation in relationto the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk .