Financial update and funding plans

Tissue Regenix Group plc

('Tissue Regenix', the 'Group' or the 'Company')

Financial update and funding plans

Tissue Regenix (AIM: TRX), the regenerative medical devices company, provides an update to its financial position.

Further to the announcement of 22 October 2025 and the temporary suspension of trading on AIM of the Company's ordinary shares, the new Senior Leadership Team has been reviewing the previously announced restatement of revenue numbers for the financial year ended 31 December 2024 ("FY24"), the impact this has on H125 adjusted EBITDA, and the cash-position and ongoing expected performance of the business.

It is now clear to the Senior Leadership Team that the Company has a substantial backlog of creditors, and very limited cash balances. Accordingly, the Company has an urgent need to raise capital by the end of November. Without additional funding the Company will not be able to continue to trade.

The Company is in discussion with its major shareholders and has clear indications of support to raise approximately £5m by way of a convertible loan note. Any fundraise will be subject to shareholder approval.

Further updates will be made in due course.

For more information, please contact:

Prior to publication, the information contained within this announcement was deemed by the Company to constitute inside information as stipulated under the UK Market Abuse Regulation. With the publication of this announcement, this information is now considered to be in the public domain.

About Tissue Regenix (www.tissueregenix.com)

Tissue Regenix is a leading medical device company in regenerative medicine. The Company's patented decellularisation technology (dCELL®) removes DNA and other cellular material from animal and human soft tissue, leaving an acellular tissue scaffold that is not rejected by the patient's body and can be used to repair diseased or damaged body structures. Current applications address many crucial clinical needs in sports medicine, foot and ankle injuries, and wound care.

In August 2017, Tissue Regenix acquired CellRight Technologies®. This biotech company specialises in regenerative medicine and is dedicated to developing high-quality, innovative tissue scaffolds to enhance healing opportunities in defects created by trauma and disease. CellRight's human tissue products may be used in spine, trauma, general orthopaedic, dental and ophthalmological surgical procedures.