7th Feb 2008 12:00
GlaxoSmithKline PLC07 February 2008 Issued: Thursday, 7th February 2008, London, U.K. Preliminary Results Announcement for the year ended 31st December 2007 GSK reports 2007 Business Performance* EPS of 99.1p up 10% CER Strong fourth quarter business performance EPS growth of 17% CERGlaxoSmithKline plc (GSK) today announces its unaudited results for the year ended 31st December 2007. The fullresults are presented under 'Income Statement' on pages 9 and 10, and are summarised below. FINANCIAL RESULTS* 2007 Growth Q4 2007 Growth £m CER% £% £m CER% £%Turnover 22,716 2 (2) 5,974 - -Business performance* Operating profit 7,931 8 2 1,926 14 13 Earnings per share 99.1p 10 4 24.4p 17 16 Total results Operating profit 7,593 3 (3) 1,588 (7) (7) Earnings per share 94.4p 5 (1) 19.6p (7) (7) Total results include restructuring charges of £338 million before tax for the quarter and full year. BUSINESS PERFORMANCE SUMMARY* • GSK delivers 2007 business performance EPS up 10% CER - at high end of guidance • 2007 dividend of 53p +10%; £6 billion of shares expected to be repurchased in 2008 • Industry-leading pipeline delivery in 2007, with 10 product approvals including Tykerb, Cervarix and Veramyst • Sustained product flow expected - 13 new product opportunities currently filed with regulators, including: Promacta (USA), Rotarix (USA), Treximet (USA) and Synflorix (EU and International) • Late stage pipeline enhancement continues with 9 new phase III programmes started in last 12 months - 34 key assets currently in phase III/registration • Consumer Healthcare delivers strong 2007 performance, with sales up 14% to £3.5 billion • In 2008, GSK expects that the impact of lower Avandia sales together with increased generic competition will lead to a mid-single digit percentage decline in business performance EPS, at constant exchange rates • Currency - 2007 Sterling EPS growth adversely impacted by 6 percentage points due to currency movements * Management reports business performance, a supplemental non-IFRS measure which excludes significant one-off restructuring charges, as it believes this is useful to an understanding of the Group's performance. 2007 business performance results exclude restructuring charges of £338 million before tax relating to the new Operational Excellence programme which commenced in October 2007. In order to illustrate underlying performance, it is the Group's practice to discuss its results in terms of constant exchange rate (CER) growth. All commentaries are presented in terms of CER and compare 2007 business performance results with 2006 total results, unless otherwise stated. See 'Accounting Presentation and Policies' on page 23. Commenting on GSK's performance for 2007 and outlook, JP Garnier, Chief Executive Officer, said: "Despite a significantsetback on Avandia, good sales performance from other areas of our broad portfolio enabled GSK to deliver 10% EPS growthin 2007 - at the high end of our guidance. The decline in Avandia sales, together with increased generic competition in the USA, will adversely impact our earningsin 2008, but looking ahead we remain confident in GSK's future. Our fast-growing vaccines business, the resurgence ofour consumer healthcare division and the strong performance of many key pharmaceutical products are all providingcontributions to growth. The momentum of our late-stage pipeline continues to enhance our business and is producing asignificant renewal of our product line - last year GSK received a record 10 product approvals and this year expectsregulatory decisions on more than 10 new product opportunities." PHARMACEUTICAL UPDATE Total pharmaceutical turnover was level for 2007 at £19.2 billion. In the United States, turnover fell 3% to £9.3 billion for the year, due to a substantial reduction in Avandia sales and generic competition to Flonase, Wellbutrin XL, Zofran and Coreg IR. Turnover in Europe was up 2% to £5.7 billion, with good performances from Seretide, vaccines and newer products offsetting the impact of generic competition and continued pricing pressure from European governments. Turnover in International was £4.3 billion, up 6%, with good growth reported in Japan (sales +10% to £867 million). Seretide/Advair sales up 10% to £3.5 billion Sales of Seretide/Advair, for asthma and COPD, rose 9% to £1.9 billion in the USA. In Europe, sales grew 9% to £1.2 billion and in International sales grew by 23% to £372 million, enhanced by its launch in Japan in June. GSK continues to see increased use of Seretide/Advair in the treatment of COPD and is in ongoing discussions with the FDA to expand the indication for use in this patient group, including assessment of data supporting a claim for reduction of exacerbations. Vaccine sales up 20% to £2 billion driven by strong US performance Vaccine sales grew strongly across all regions with US sales up 44% for the year to £628 million, sales in Europe up 14% to £814 million and sales in International markets up 8% to £551 million. In the USA, sales of hepatitis vaccines grew 33% to £199 million, and sales of Infanrix/Pediarix, rose 23% to £196 million. GSK's pre-pandemic influenza vaccine achieved sales of £146 million for the year and discussions regarding further orders continue with governments. Sales of new two-dose vaccine, Rotarix, to prevent rotavirus gastroenteritis, doubled to £91 million in 2007 with strong growth in both Europe and International. In the USA, the FDA accepted the Rotarix file for review in August last year and GSK expects a response in the first half of this year. Cervarix, GSK's vaccine to prevent cervical cancer, has been approved in 51 countries around the world, and negotiations with governments regarding reimbursement and tender decisions are ongoing. Further licensing applications have been submitted in 27 countries including Japan, where the vaccine has been granted priority review. In the USA, the FDA issued a Complete Response letter in December, to the company's licence application made earlier in the year. GSK plans to submit a response to the FDA in the second quarter and will continue discussions with the agency regarding the application. Avandia product group sales declined to £1.2 billion Sales of Avandia products, for the treatment of type 2 diabetes, fell 29% to £780 million in the USA, with fourth quarter sales down 55% to £130 million, following publication in May of a meta-analysis. Outside the USA, sales in Europe grew 4% for the year to £227 million, and in International markets, sales declined 7% to £212 million. Other key pharmaceutical growth drivers delivered combined sales of £2.9 billion, up 25% Sales of Lamictal, for the treatment of epilepsy and bipolar disorder, grew 18% to £1.1 billion, driven by sales in the USA which were up 26% to £892 million. The company expects to respond to the FDA's approvable letter for Lamictal XR around mid-year. Sales of Valtrex, for herpes, rose 18% to £934 million, with US sales up 20% to £668 million, driven by increased use of the product for prevention of transmission. Sales in Europe grew 9% to £120 million and in International grew 13% to £146 million. Sales of Requip, for Parkinson's Disease/Restless Legs Syndrome, grew 36% to £346 million. Requip XL, a new once-daily formulation for Parkinson's Disease, has now been approved in 13 European countries and launched in 7 markets. Further European approvals are anticipated during 2008. In the USA, GSK expects a response from the FDA on its application for Requip XL during the first half of 2008. Avodart, for benign prostatic hyperplasia (enlarged prostate), continued to perform strongly with sales up 38% to £285 million for the year. Positive data from the CombAT study (assessing use of Avodart and the alpha-blocker, tamsulosin, as combination therapy) were recently published in the Journal of Urology. GSK has filed for a co-prescription indication in the USA, Europe and other International markets. A response is expected from the FDA during the second quarter of 2008. GSK's co-promotion income for Boniva/Bonviva, the only once-monthly medicine for post-menopausal osteoporosis, was up 79% to £161 million. Arixtra, for deep vein thrombosis and pulmonary embolism, delivered strong growth with sales up 81% to £100 million. Sales grew strongly in Europe (up 70% to £39 million), following approval last year for the treatment of specific acute coronary syndromes (ACS). The ACS approval was supported by data showing that Arixtra had similar efficacy to Lovenox, but Arixtra patients had a significantly lower risk of bleeding and a significant mortality benefit compared to Lovenox. In the USA, GSK anticipates submitting a response to the FDA's approvable letter for a potential ACS indication in the first half of 2008. Newly launched NCEs Tykerb/Tyverb, for breast cancer, achieved sales of £51 million for the year, with US sales of £36 million following successful launch of the product in March. In December, the EMEA granted a positive opinion for approval of Tyverb and a decision for approval from Japanese regulatory authorities is expected later this year. Veramyst/Avamys, for allergic rhinitis, generated sales of £21 million, following launch in the USA in June 2007. In January 2008, GSK received European approval for Avamys nasal spray to treat allergic rhinitis in adults and children. A licence application is currently under review with regulatory authorities in Japan. Altabax/Altargo, a first in class antibacterial for treatment of skin infections, recorded initial sales of £11 million following approval in 2007. As a novel topical antibacterial, Altabax/Altargo provides physicians with an effective new treatment option, requiring half as many doses in fewer days than other topical antibiotics, and has shown a low potential for the development of resistance. Other products Total sales of HIV products were over £1.4 billion, down 1%. Competition to older products, Combivir (-10% to £455 million) and Epivir (-20% to £156 million), was partially offset by strong sales growth of new products Epzicom/Kivexa (+39% to £324 million) and Lexiva (+13% to £141 million). Sales of Relenza, an antiviral treatment for flu, were £262 million, more than double the prior year, driven primarily by one-off government orders for stockpiling against a possible flu pandemic. Sales of Imitrex/Imigran, for migraine were £685 million, up 3%, with sales growth in the USA (up 9% to £558 million) offset by the impact of generic competition in other regions. Sales of Coreg products, for heart disease, fell 18% to £587 million, following the introduction of generic competition to Coreg IR in September. Sales of Coreg CR, which was launched in March 2007, were £88 million. Other product sales affected by generic competition were Wellbutrin (-37% to £529 million), Flonase (-34% to £199 million) and Zofran (-77% to £196 million). Fourth quarter pharmaceutical turnover down 2% to £5.0 billion Fourth quarter pharmaceutical performance was impacted by declining US turnover, which was down 8% to £2.3 billion adversely impacted by lower Avandia sales and generic competition to Coreg IR, Flonase, Wellbutrin XL and Zofran. In Europe, total pharmaceutical turnover grew 4% to almost £1.6 billion and in International markets rose 6% to £1.2 billion. PHARMACEUTICAL PIPELINE UPDATE R&D pipeline progress In 2007, GSK maintained momentum in delivering its late-stage pipeline, receiving 10 product approvals andfiling 10 product applications. GSK currently has 13 new product opportunities filed with regulators. GSKalso commenced 9 new phase III clinical development programmes in 2007 and now has 34 key assets in phase III/registration. 2007 Approvals Products currently filed 2007 progressed into Phase IIIAdoair (Japan) Avodart & alpha blocker co-Rx belimumab* (LymphoStat B)Altabax/Altargo* (USA & EU) Cervarix (USA & Japan) elesclomol*Arixtra ACS (EU) Entereg POI*+ GSK 1838262* (XP13512)Arixtra VTE (Japan) H5N1 vaccine* (EU) MAGE-A3 therapeutic vaccine*Atriance (EU) Kinrix (USA) MenACWY vaccine*Cervarix* (EU) Lamictal XR (USA) ofatumumab* (RA)Requip XL (EU) Lunivia* (EU) Promacta* (Hep C)Tykerb* (USA & EU) Promacta* (USA) Tykerb + Armala* (IBC)Veramyst* (USA) Requip XL (USA) Tykerb (Head & Neck)Wellbutrin XL (EU) Rotarix (USA) Synflorix* (EU & Int'l) Treximet+ Volibris* (EU) * Bold = NCEs (first launch in major market or currently in clinical development)+ Additional data filed in 2007 Recent filings In December, GSK filed Promacta, an oral platelet growth factor therapy, with the FDA for the short-term treatment of chronic idiopathic thrombocytopenic purpura. Also in December, new data from the ongoing EXTEND study were presented at the American Society of Haematology meeting demonstrating that Promacta sustains increased platelet counts during long-term treatment. Following completion of an ongoing phase III study (RAISE), GSK intends to file Promacta for use as a long-term treatment during the second half of 2008. GSK filed Synflorix, for approval in Europe and International markets in December. With a dual mode of action against S. pneumoniae and non-typeable Haemophilus influenzae, Synflorix has the potential to protect children against invasive pneumococcal disease beyond that offered by current vaccines, and bacterial respiratory infections such as acute middle ear infections (otitis media). In January, additional supportive data for Treximet, a new treatment for acute migraine, were submitted to the FDA. Treximet is a combination of gold-standard migraine treatment, sumatriptan, and naproxen sodium in a single tablet designed to target multiple mechanisms of migraine with enhanced efficacy and duration of treatment response. A decision regarding the licence application for Treximet is expected from the FDA during the first half of 2008. An FDA Advisory Committee meeting was held in January to discuss use of Entereg for the management of post-operative ileus (POI). A decision from the FDA is expected in early February. Q4 late-stage pipeline progress GSK1838262 - results from a second positive phase III trial demonstrating the potential of '262 as a treatment for Restless Legs Syndrome were announced last month. Additional phase III data are expected during the first quarter of 2008, with an FDA filing planned for the third quarter. Rezonic - positive data from two phase III trials in chemotherapy-induced nausea and vomiting were received in 2007 and GSK expects to file Rezonic for use in this indication and for the treatment of post-operative nausea and vomiting in 2008. ofatumumab - two phase III studies to assess use of ofatumumab to treat rheumatoid arthritis were initiated in November. In addition, a phase II study in diffuse large B-cell lymphoma commenced in December. Tykerb+Armala (pazopanib) - phase III trials commenced in December 2007 with an initial study evaluating use of the combination to treat women with metastatic inflammatory breast cancer. This will be the first trial of its kind to be conducted without the use of chemotherapy. elesclomol (formerly STA-4783) - progressed into phase III development for treatment of metastatic melanoma in November. In January 2008 elesclomol was granted US orphan drug designation for this indication. Horizon - during the fourth quarter, GSK advanced its development programme for a next-generation once daily combination product for the treatment of asthma into late-stage clinical trials. Large phase IIb asthma studies for '698, an inhaled corticosteroid, and '444, a long-acting beta agonist, were initiated with results expected during the second half of 2008. darapladib (LpPLA2 inhibitor for treatment of atherosclerosis) - phase II dose-ranging data will be presented at the American College of Cardiology meeting in March. Data from the IBIS 2 imaging study will shortly be submitted to a major medical journal. Q4 acquisitions and collaborations In December, GSK acquired Reliant Pharmaceuticals and its portfolio of speciality medicines combating heart disease, including US marketing rights to Lovaza (omega-3-acid ethyl esters). Lovaza is the only prescription omega-3 medicine approved by the FDA for the treatment of adult patients with very high levels of triglycerides and generated net sales of £157 million, in 2007, representing an increase of 104% over 2006. GSK strengthened its oncology portfolio in December by exercising its option with Exelixis to develop XL880, a small molecule compound currently in phase II trials in patients with papillary renal cell carcinoma, gastric cancer and head and neck cancer. During the fourth quarter, GSK formed a number of worldwide strategic alliances to discover, develop and market candidate compounds. These include an alliance with OncoMed to develop novel antibody therapeutics to target cancer stem cells, Santaris to develop compounds based on unique locked nucleic acid technology against viral diseases and Galapagos to develop novel antibacterials and antivirals. CONSUMER HEALTHCARE UPDATE Consumer Healthcare delivers strong 2007 performance with sales up 14% to nearly £3.5 billion Consumer Healthcare maintained strong growth momentum with total sales up 14% to nearly £3.5 billion. In the USA, sales grew 30% to £990 million. In Europe, sales grew 7% to £1.6 billion and, in International, sales grew 10% to £934 million. • Over-the-counter medicine sales grew 20% to £1.7 billion, with Panadol up 14% to £262 million and alli sales of £150 million since launch in the USA in June. Smoking Control products declined 6% to £314 million. Breathe Right and FiberChoice, added to the portfolio with the acquisition of CNS in December 2006, achieved combined sales of £81 million. • Oral care sales grew 8% to over £1 billion. Sales of Aquafresh were up 12% to £308 million, helped by the success of new Aquafresh White Trays. Sensodyne also grew strongly, up 16% for the year to £293 million, driven by a successful launch of Sensodyne ProNamel. • Nutritional healthcare products sales grew 9% to £716 million. Lucozade grew 16% to £347 million, and Horlicks grew 12% to £174 million. Ribena sales were down 7% to £156 million. FINANCIAL REVIEW Dividends The Board has declared a fourth interim dividend of 16 pence per share resulting in a dividend for the year of 53 pence,a five pence increase over the dividend of 48 pence per share for 2006. The equivalent interim dividend receivable byADR holders is 62.7264 cents per ADS based on an exchange rate of £1/$1.9602. The ex-dividend date will be 13thFebruary 2008, with a record date of 15th February 2008 and a payment date of 10th April 2008. Share buy-back programme GSK repurchased £3,750 million of shares in 2007 of which £3,537 million are held as Treasury shares and £213 millionhave been cancelled. Share repurchases of £2.5 billion were made as part of the new £12 billion share buy-backprogramme announced in July 2007. A further £6 billion of repurchases under this programme are expected in 2008. Operational Excellence GSK announced in October 2007 a significant new £1.5 billion Operational Excellence programme to improve theeffectiveness and productivity of its operations. This new programme is expected to deliver annual pre-tax savings of £700 million by 2010. GSK expects to realise themajority of annual savings within the first two years of the programme, with approximately £350 million expected by 2008and £550 million by 2009. These savings will partly mitigate the expected impact to 2008 earnings from genericcompetition and lower Avandia sales and the associated adverse impact on GSK's gross margin. In Q4 2007, GSK has introduced a 3-column approach to the income statement. 'Business Performance' shows GSK'sunderlying results excluding restructuring costs related to the new Operational Excellence programme announced inOctober 2007 and significant acquisitions. There were no significant acquisition-related restructuring costs incurredin 2006 or 2007. The middle column shows restructuring costs and the 'Total' column shows the full IFRS statutoryresults. One-off charges of £338 million before tax relating to the new Operational Excellence programme were recorded in Q42007. Operating profit and earnings per share - full year Business performance operating profit of £7,931 million increased by 8% in CER terms compared with 2006 and was aboveturnover growth of 2% in CER terms, reflecting lower SG&A and R&D costs and higher other operating income. In the year, gains from asset disposals were £109 million (£169 million in 2006), costs for legal matters were £255million (£333 million in 2006), fair value movements on financial instruments resulted in an income of £41 million(income of £29 million in 2006) and charges related to previous restructuring programmes were £92 million (£205 millionin 2006). The business performance operating profit impact of these items was a £197 million charge in 2007 (£340million charge in 2006). Business performance profit after taxation increased by 8% in CER terms, in line with the increase in operating profitas a lower tax rate for the year was offset by higher net interest costs. Business performance EPS of 99.1 pence increased 10% in CER terms (4% increase in sterling terms) compared with 2006.The adverse currency impact of 6 percentage points on EPS growth predominantly reflected the strength of sterlingagainst the US dollar. Total operating profit, including restructuring costs of £338 million, was £7,593 million and total EPS was 94.4 pence. Operating profit and earnings per share - Q4 2007 Business performance operating profit of £1,926 million increased by 14% in CER terms compared with Q4 2006 and wasabove flat turnover growth, reflecting lower SG&A and R&D costs and higher other operating income. Costs of goods increased to 25.6% (2006: 24.2%) reflecting unfavourable product and regional mix and one-off itemsincluding stock write-offs. Excluding one-off items, cost of goods was approximately 24.2% of turnover. In the quarter, gains from asset disposals were £20 million (£3 million in 2006), costs for legal matters were £62million (£81 million in 2006), fair value movements on financial instruments resulted in income of £51 million (£46million income in 2006) and charges related to previous restructuring programmes were £43 million (£132 million in2006). The business performance operating profit impact of these items was a £34 million charge in 2007 (£164 millioncharge in 2006). Business performance profit after taxation increased by 12% in CER terms, which was slightly lower than the growth inoperating profit and reflected higher net interest costs partly offset by a lower tax rate. Business performance EPS of24.4 pence increased 17% in CER terms (16% increase in sterling terms) compared with 2006, benefiting from the movementshighlighted in the previous paragraph. Total operating profit for the quarter, including restructuring costs, was £1,588 million and total EPS was19.6 pence. Currencies The 2007 results are based on average exchange rates, principally £1/$2.00, £1/Euro 1.46 and £1/Yen 235. The period-endexchange rates were £1/$1.99, £1/Euro 1.36 and £1/Yen 222. If exchange rates were to hold at the average January 2008levels (£1/$1.99, £1/Euro 1.35 and £1/Yen 217) for the rest of the year, the positive currency impact on businessperformance EPS growth for the full-year would be around 3 percentage points. Earnings guidance In 2008, GSK expects that the impact of lower Avandia sales together with increased generic competition will lead to amid-single digit percentage decline in business performance EPS, at constant exchange rates. GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed toimproving the quality of human life by enabling people to do more, feel better and live longer. For company informationincluding a copy of this announcement and details of the company's updated product development pipeline, visit GSK atwww.gsk.com. Enquiries: UK Media Philip Thomson (020) 8047 5502 Claire Brough (020) 8047 5502 Alice Hunt (020) 8047 5502 Joss Mathieson (020) 8047 5502 Gwenan White (020) 8047 5502 US Media Nancy Pekarek (215) 751 7709 Mary Anne Rhyne (919) 483 2839 European Analyst / Investor David Mawdsley (020) 8047 5564 Sally Ferguson (020) 8047 5543 Gary Davies (020) 8047 5503 US Analyst / Investor Frank Murdolo (215) 751 7002 Tom Curry (215) 751 5419 Brand names appearing in italics throughout this document are trademarks of GSK or associated companies with theexception of Levitra, a trademark of Bayer, Bonviva/Boniva, a trademark of Roche, Entereg is a trademark of the AdolorCorporation in the USA and Vesicare, a trademark of Astellas Pharmaceuticals in many countries and of YamanouchiPharmaceuticals in certain countries, all of which are used under licence by the Group. Cautionary statement regarding forward-looking statements Under the safe harbor provisions of the US Private Securities Litigation Reform Act of 1995, the company cautionsinvestors that any forward-looking statements or projections made by the company, including those made in thisAnnouncement, are subject to risks and uncertainties that may cause actual results to differ materially from thoseprojected. Factors that may affect the Group's operations are described under 'Risk Factors' in the 'Business Review'in the company's Annual Report 2006. INCOME STATEMENT Year ended 31st December 2007 Business Growth Restructuring performance 2007 Total Total 2007 2007 2006 £m CER% £m £m £m --------- --------- --------- --------- ---------Turnover:Pharmaceuticals 19,233 - 19,233 20,078Consumer Healthcare 3,483 14 3,483 3,147 --------- --------- --------- ---------TURNOVER 22,716 2 22,716 23,225 Cost of sales (5,206) 6 (111) (5,317) (5,010) --------- --------- --------- ---------Gross profit 17,510 1 (111) 17,399 18,215 Selling, general and administration (6,817) (2) (137) (6,954) (7,257)Research and development (3,237) (3) (90) (3,327) (3,457)Other operating income 475 475 307 --------- --------- --------- --------- Operating profit:Pharmaceuticals 7,191 8 (334) 6,857 7,125Consumer Healthcare 740 11 (4) 736 683 --------- --------- --------- ---------OPERATING PROFIT 7,931 8 (338) 7,593 7,808 Finance income 262 262 287Finance expense (453) (453) (352)Share of after tax profits of associates 50 50 56and joint ventures --------- --------- --------- --------- PROFIT BEFORE TAXATION 7,790 6 (338) 7,452 7,799 Taxation (includes total overseas tax of £1,756 million (2006: £1,912 (2,219) 77 (2,142) (2,301) million)Tax rate % 28.5% 28.7% 29.5% --------- --------- --------- ---------PROFIT AFTER TAXATION FOR THE PERIOD 5,571 8 (261) 5,310 5,498 --------- --------- --------- --------- Profit attributable to minority interests 96 - 96 109Profit attributable to shareholders 5,475 (261) 5,214 5,389 --------- --------- --------- --------- 5,571 (261) 5,310 5,498 --------- --------- --------- --------- EARNINGS PER SHARE 99.1p 10 94.4p 95.5p --------- --------- --------- --------- Diluted earnings per share 98.3p 93.7p 94.5p --------- --------- --------- --------- INCOME STATEMENT Three months ended 31st December 2007 Business Growth Restructuring performance Q4 2007 Total Total Q4 2007 Q4 2007 Q4 2006 £m CER% £m £m £m --------- --------- --------- --------- ---------Turnover:Pharmaceuticals 5,047 (2) 5,047 5,136Consumer Healthcare 927 11 927 823 --------- --------- --------- ---------TURNOVER 5,974 - 5,974 5,959 Cost of sales (1,528) 5 (111) (1,639) (1,445) --------- --------- --------- ---------Gross profit 4,446 (1) (111) 4,335 4,514 Selling, general and administration (1,686) (13) (137) (1,823) (1,934)Research and development (953) (2) (90) (1,043) (980)Other operating income 119 119 100 --------- --------- --------- --------- Operating profit:Pharmaceuticals 1,707 15 (334) 1,373 1,501Consumer Healthcare 219 8 (4) 215 199 --------- --------- --------- ---------OPERATING PROFIT 1,926 14 (338) 1,588 1,700 Finance income 52 52 83Finance expense (119) (119) (86)Share of after tax profits of associates and 10 10 13joint ventures --------- --------- --------- --------- PROFIT BEFORE TAXATION 1,869 10 (338) 1,531 1,710 Taxation (532) 77 (455) (505)Tax rate % 28.5% 29.7% 29.5% --------- --------- --------- ---------PROFIT AFTER TAXATION FOR THE PERIOD 1,337 12 (261) 1,076 1,205 --------- --------- --------- --------- Profit attributable to minority interests 19 - 19 24Profit attributable to shareholders 1,318 (261) 1,057 1,181 --------- --------- --------- --------- 1,337 (261) 1,076 1,205 --------- --------- --------- --------- EARNINGS PER SHARE 24.4p 17 19.6p 21.0p --------- --------- --------- --------- Diluted earnings per share 24.2p 19.4p 20.8p --------- --------- --------- --------- PHARMACEUTICAL TURNOVER Year ended 31st December 2007 Total USA Europe International ---------------- ---------------- -------------- ------------- £m CER% £m CER% £m CER% £m CER% ------ ----- ------ ----- ----- ----- ---- -----RESPIRATORY 5,032 5 2,377 4 1,772 4 883 10Seretide/Advair 3,499 10 1,891 9 1,236 9 372 23Flixotide/Flovent 621 (1) 284 3 161 (8) 176 (2)Serevent 269 (4) 74 (7) 134 (5) 61 -Flixonase/Flonase 199 (34) 72 (60) 51 - 76 5 CENTRAL NERVOUS SYSTEM 3,348 (2) 2,377 (1) 513 (14) 458 6Seroxat/Paxil 553 (6) 143 (12) 122 (19) 288 5 Paxil IR 400 (6) 7 (63) 122 (19) 271 4 Paxil CR 153 (4) 136 (6) - - 17 13Wellbutrin 529 (37) 512 (38) 4 100 13 (13) Wellbutrin IR, SR 75 (23) 63 (26) 2 - 10 - Wellbutrin XL 454 (39) 449 (39) 2 - 3 (40)Imigran/Imitrex 685 3 558 9 89 (25) 38 (2)Lamictal 1,097 18 892 26 145 (18) 60 13Requip 346 36 238 46 91 11 17 64 ANTI-VIRALS 3,028 13 1,494 19 870 1 664 13HIV 1,442 (1) 637 (2) 612 (2) 193 5Combivir 455 (10) 195 (11) 192 (12) 68 (1)Trizivir 233 (9) 120 (8) 99 (13) 14 7Epivir 156 (20) 53 (16) 67 (26) 36 (14)Ziagen 109 (3) 45 2 37 (10) 27 (4)Agenerase, Lexiva 141 13 78 14 53 10 10 22Epzicom/Kivexa 324 39 142 23 149 54 33 74 Herpes 1,041 15 678 20 151 4 212 6Valtrex 934 18 668 20 120 9 146 13Zovirax 107 (8) 10 - 31 (11) 66 (7) Zeffix 168 8 13 8 24 4 131 9Relenza 262 >100 131 - 76 21 55 >100 METABOLIC 1,514 (15) 895 (24) 294 15 325 (2)Avandia products 1,219 (22) 780 (29) 227 4 212 (7) Avandia 877 (34) 592 (40) 113 (10) 172 (14) Avandamet 292 49 147 85 111 20 34 35 Avandaryl 50 26 41 10 3 - 6 >100Bonviva/Boniva 161 79 115 49 45 >100 1 - VACCINES 1,993 20 628 44 814 14 551 8Hepatitis 529 14 199 33 235 3 95 8Influenza 320 93 193 >100 93 >100 34 (19)Infanrix/Pediarix 543 9 196 23 275 (3) 72 26Boostrix 66 15 40 5 19 27 7 75Rotarix 91 >100 - - 23 >100 68 79Cervarix 10 - - - 9 - 1 - CARDIOVASCULAR AND UROGENITAL 1,554 - 970 (2) 412 3 172 7Coreg 587 (18) 581 (19) - - 6 17 Coreg CR 88 - 88 - - - - - Coreg IR 499 (31) 493 (31) - - 6 -Levitra 49 23 47 24 2 100 - -Avodart 285 38 175 44 86 23 24 56Arixtra 100 81 55 88 39 70 6 100Fraxiparine 184 (12) - - 160 (12) 24 (17)Vesicare 50 69 50 69 - - - - ANTI-BACTERIALS 1,330 (1) 195 (3) 612 (3) 523 3Augmentin 530 (6) 67 (23) 250 (7) 213 5 ONCOLOGY AND EMESIS 477 (54) 272 (65) 139 (10) 66 (14)Zofran 196 (77) 78 (88) 71 (34) 47 (21)Hycamtin 119 10 70 6 42 21 7 -Tykerb 51 - 36 - 13 - 2 - OTHER 957 1 65 (18) 266 - 626 4Zantac 168 (24) 33 (51) 42 (19) 93 (8) ---------------- --------------- --------------- -------------- 19,233 - 9,273 (3) 5,692 2 4,268 6 ---------------- --------------- --------------- -------------- Pharmaceutical turnover includes co-promotion income. PHARMACEUTICAL TURNOVER Three months ended 31st December 2007 Total USA Europe International ---------------- ---------------- -------------- ------------- £m CER% £m CER% £m CER% £m CER% ------ ----- ------ ----- ----- ----- ---- -----RESPIRATORY 1,363 8 632 7 478 5 253 12Seretide/Advair 958 12 513 9 336 10 109 37Flixotide/Flovent 175 2 81 8 44 - 50 (6)Serevent 71 (5) 19 (9) 35 - 17 (11)Flixonase/Flonase 32 (35) 1 - 12 - 19 - CENTRAL NERVOUS SYSTEM 899 1 637 1 133 (8) 129 9eroxat/Paxil 151 (7) 39 (18) 29 (23) 83 8 Paxil IR 112 (2) 5 33 29 (23) 78 7 Paxil CR 39 (18) 34 (22) - - 5 25Wellbutrin 130 (36) 125 (38) 1 - 4 25 Wellbutrin IR, SR 16 (32) 13 (41) - - 3 33 Wellbutrin XL 114 (36) 112 (37) 1 - 1 -Imigran/Imitrex 187 11 153 16 24 (8) 10 (9)Lamictal 301 21 247 27 38 (10) 16 21Requip 95 26 64 29 25 14 6 67 ANTI-VIRALS 791 13 392 23 207 (7) 192 18HIV 359 (1) 155 (4) 156 1 48 4Combivir 108 (10) 45 (16) 45 (10) 18 13Trizivir 56 (10) 28 (9) 25 (8) 3 (25)Epivir 37 (16) 13 (7) 15 (22) 9 (20)Ziagen 28 (4) 11 - 9 (10) 8 -Agenerase, Lexiva 36 9 19 - 14 8 3 67Epzicom/Kivexa 90 29 37 18 43 45 10 14 Herpes 283 19 184 24 41 6 58 13Valtrex 255 23 181 26 33 11 41 20Zovirax 28 (10) 3 (50) 8 (11) 17 - Zeffix 42 (2) 3 33 6 - 33 (6)Relenza 75 >100 41 - 4 (91) 30 >100 METABOLIC 321 (33) 166 (47) 79 7 76 (13)Avandia products 231 (44) 130 (55) 57 (5) 44 (28) Avandia 160 (52) 99 (59) 25 (20) 36 (33) Avandamet 64 (7) 26 (19) 31 7 7 (11) Avandaryl 7 (57) 5 (71) 1 - 1 -Bonviva/Boniva 52 59 38 39 15 >100 (1) - VACCINES 634 18 204 29 258 24 172 1Hepatitis 147 13 54 28 65 3 28 12Influenza 174 62 99 68 56 (70) 19 (20)Infanrix/Pediarix 137 (2) 44 (4) 74 (4) 19 12Boostrix 13 (28) 6 (54) 5 - 2 -Rotarix 39 70 - - 7 >100 32 60Cervarix 9 - - - 9 - - - CARDIOVASCULAR AND UROGENITAL 298 (31) 136 (51) 113 5 49 26Coreg 23 (91) 23 (91) - - - - Coreg CR 33 - 34 - - - (1) - Coreg IR (10) - (11) - - - 1 -Levitra 11 - 11 - 2 - (2) -Avodart 83 36 49 44 26 26 8 17Arixtra 29 43 16 42 11 57 2 -Fraxiparine 51 (9) - - 43 (9) 8 (11)Vesicare 14 67 14 67 - - - - ANTI-BACTERIALS 370 2 52 (5) 176 2 142 6Augmentin 146 (2) 15 (36) 71 1 60 9 ONCOLOGY AND EMESIS 100 (54) 45 (72) 38 9 17 (6)Zofran 22 (88) (7) - 17 (24) 12 (21)Hycamtin 31 11 17 - 12 25 2 50Tykerb 19 - 12 - 5 - 2 - OTHER 271 4 33 89 80 (4) 158 (2)Zantac 43 (22) 7 (56) 11 (23) 25 - ---------------- ---------------- -------------- --------------- 5,047 (2) 2,297 (8) 1,562 4 1,188 6 ---------------- ---------------- --------------- --------------- Pharmaceutical turnover includes co-promotion income. CONSUMER HEALTHCARE TURNOVER Year ended 31st December 2007 2007 Growth £m CER% --------- ---------Over-the-counter medicines 1,718 20Analgesics 410 11Dermatological 175 10Gastrointestinal 262 9Respiratory tract 244 45Smoking control 314 (6)Natural wellness support 125 (3)Weight management 150 - Oral care 1,049 8Nutritional healthcare 716 9 --------- ---------Total 3,483 14 --------- --------- CONSUMER HEALTHCARE TURNOVER Three months ended 31st December 2007 Q4 2007 Growth £m CER% --------- ---------Over-the-counter medicines 480 18Analgesics 106 9Dermatological 48 14Gastrointestinal 68 6Respiratory tract 83 41Smoking control 86 (15)Natural wellness support 35 3Weight management 40 - Oral care 275 3Nutritional healthcare 172 8 --------- ---------Total 927 11 --------- --------- FINANCIAL REVIEW - INCOME STATEMENT Operating profit - business performance 2007 2006 Growth ---------------------- -------------------- --------------- % of % of £m turnover £m turnover CER% £% ------ ------ ------ ------ ----- -----Turnover 22,716 100.0 23,225 100.0 2 (2) Cost of sales (5,206) (22.9) (5,010) (21.6) 6 4Selling, general and administration (6,817) (30.0) (7,257) (31.2) (2) (6)Research and development (3,237) (14.3) (3,457) (14.9) (3) (6)Other operating income 475 2.1 307 1.3 ------ ------ ------ ------ ----- ----Operating profit 7,931 34.9 7,808 33.6 8 2 ------ ------ ------ ------ ----- ---- Business performance operating margin increased 1.3 percentage points, as sterling operating profit increased 2% whilesterling turnover declined 2%. Cost of sales as a percentage of turnover increased by 1.3 percentage points. At constant exchange rates, cost of salesas a percentage of turnover increased by 0.8 percentage points, reflecting unfavourable product and regional mix. SG&A costs as a percentage of turnover decreased 1.2 percentage points compared with 2006. R&D expenditure declined 0.6 percentage points reflecting lower charges related to old restructuring activity and lowerimpairment charges. Excluding these items, expenditure was in line with last year. Pharmaceuticals R&D expenditurerepresented 16.2% (2006: 16.7%) of pharmaceutical turnover. Other operating income includes royalty income, equity investment disposals and impairments, product disposals and fairvalue adjustments to financial instruments. Other operating income was £475 million in 2007 (2006: £307 million). Theincrease is primarily due to higher royalty income (£216 million in 2007 compared with £94 million in 2006), favourablefair value movements on financial instruments (£41 million in 2007 compared with £29 million in 2006), and the Rochelitigation settlement relating to carvedilol, partially offset by lower asset disposal profits. Operating profit - total results Total operating profit for 2007 was £7,593 million, up 3% CER, but down 3% in sterling terms compared with 2006. Thisincluded £338 million of restructuring charges under the new Operational Excellence programme; £111 million was chargedto cost of sales, £137 million to SG&A and £90 million to R&D. There were no such charges in 2006. Taxation The charge for taxation on business performance profit, amounting to £2,219 million, represents an effective tax rate of28.5% (2006 - 29.5%). The charge for taxation on total profit amounts to £2,142 million. The Group's balance sheet at31st December 2007 included a tax payable liability of £826 million and a tax recoverable asset of £58 million. The Group's main open tax issues are in the UK, the US, Canada and Japan. GSK continues to be in dispute with HMRC primarily in respect of transfer pricing and Controlled Foreign Companies ('CFC') matters for the years 1994 to date. HMRC have not yet formalised claims in respect of these matters and GSK isseeking to resolve them in discussions with HMRC. There continues however to be a wide difference between the Group andHMRC positions, which may ultimately need to be settled by litigation. Following its audit of the period 2001 to 2003, the IRS has in Notices of Proposed Adjustment challenged deductionsarising from intercompany financing arrangements for those years, which the company disagrees with and will vigorouslycontest. GSK estimates that the IRS claim for tax and interest at 31st December 2007 net of federal tax relief forthese years, is $680 million. GSK believes, supported by external professional advice, that this claim has no merit andthat no adjustment is warranted. If, contrary to GSK's view, the IRS prevailed in its argument before a court, thecompany would expect to have an additional liability for the four year unaudited period 2004-2007 proportionate to itsliability for the three year audited period 2001-2003. In the event that the company is not able to resolve this issuewith the IRS, a court decision would not be expected before 2010. Lower courts in Japan have upheld claims by the tax authorities for Yen 39 billion (£177 million) relating to JapaneseCFC legislation. The company has paid and fully provided for the full tax but is pursuing a claim for refund to theJapanese Supreme Court. In Canada a court hearing in respect of transfer pricing in the early 1990s was completed inJuly 2007. GSK is still awaiting the court's judgement. GSK uses the best advice in determining its transfer pricing methodology and in seeking to manage transfer pricing andother taxation issues to a satisfactory conclusion and, on the basis of external professional advice, continues tobelieve that it has made adequate provision for the liabilities likely to arise from open assessments. The ultimateliability for such matters may vary from the amounts provided and is dependent upon the outcome of litigationproceedings and negotiations with the relevant tax authorities. Weighted average number of shares 2007 2006 millions millions -------- --------Weighted average number of shares - basic 5,524 5,643Dilutive effect of share options and share awards 43 57 -------- --------Weighted average number of shares - diluted 5,567 5,700 -------- -------- Q4 2007 Q4 2006 millions millions -------- --------Weighted average number of shares - basic 5,405 5,618Dilutive effect of share options and share awards 38 51 -------- --------Weighted average number of shares - diluted 5,443 5,669 -------- -------- The number of shares in issue, excluding those held by the ESOP Trusts and those held as Treasury shares at 31stDecember 2007, was 5,375 million (31st December 2006: 5,603 million). Dividends Paid/ Pence per payable share £m ------- ---- ----2007First interim 12th July 2007 12 670Second interim 11th October 2007 12 667Third interim 10th January 2008 13 708Fourth interim 10th April 2008 16 860 ---- ---- 53 2,905 ---- ----2006First interim 6th July 2006 11 619Second interim 5th October 2006 11 620Third interim 4th January 2007 12 671Fourth interim 12th April 2007 14 785 ---- ---- 48 2,695 ---- ---- The liability for an interim dividend is only recognised when it is paid, which is usually after the accounting periodto which it relates. The third and fourth interim dividends for 2007 have not been recognised in these results. STATEMENT OF RECOGNISED INCOME AND EXPENSE 2007 2006 £m £m ---- ----Exchange movements on overseas net assets 425 (390)Tax on exchange movements 21 (78)Fair value movements on available-for-sale investments (99) 84Deferred tax on fair value movements on available-for-sale investments 19 (15)Exchange movements on goodwill in reserves (14) 31Actuarial gains on defined benefit plans 671 429Deferred tax on actuarial movements in defined benefit plans (195) (161)Fair value movements on cash flow hedges (6) (5)Deferred tax on fair value movements on cash flow hedges 2 2 ---- ----Net gains/(losses) recognised directly in equity 824 (103) Profit for the year 5,310 5,498 ---- ----Total recognised income and expense for the year 6,134 5,395 ---- ---- Total recognised income and expense for the year attributable to:Shareholders 6,012 5,307Minority interests 122 88 ---- ---- 6,134 5,395 ---- ---- BALANCE SHEET 31st December 31st December 2007 2006 £m £mASSETS ---- ----Non-current assetsProperty, plant and equipment 7,821 6,930Goodwill 1,370 758Other intangible assets 4,456 3,293Investments in associates and joint ventures 329 295Other investments 517 441Deferred tax assets 2,196 2,123Derivative financial instruments 1 113Other non-current assets 687 608 ---- ----Total non-current assets 17,377 14,561 ---- ----Current assetsInventories 3,062 2,437Current tax recoverable 58 186Trade and other receivables 5,495 5,237Derivative financial instruments 475 80Liquid investments 1,153 1,035Cash and cash equivalents 3,379 2,005Assets held for sale 4 12 ---- ----Total current assets 13,626 10,992 ---- ----TOTAL ASSETS 31,003 25,553 ---- ----LIABILITIESCurrent liabilitiesShort-term borrowings (3,504) (718)Trade and other payables (4,861) (4,831)Derivative financial instruments (262) (40)Current tax payable (826) (621)Short-term provisions (892) (1,055) ---- ----Total current liabilities (10,345) (7,265) ---- ----Non-current liabilitiesLong-term borrowings (7,067) (4,772)Deferred tax liabilities (887) (595)Pensions and other post-employment benefits (1,383) (2,339)Other provisions (1,035) (528)Derivative financial instruments (8) (60)Other non-current liabilities (368) (346) ---- ----Total non-current liabilities (10,748) (8,640) ---- ----TOTAL LIABILITIES (21,093) (15,905) ---- ----NET ASSETS 9,910 9,648 ---- ---- EQUITYShare capital 1,503 1,498Share premium account 1,266 858Retained earnings 6,475 6,965Other reserves 359 65 ---- ----Shareholders' equity 9,603 9,386 Minority interests 307 262 ---- ----TOTAL EQUITY 9,910 9,648 ---- ---- RECONCILIATION OF MOVEMENTS IN EQUITY 2007 2006 £m £m ---- ----Total equity at beginning of year 9,648 7,570Total recognised income and expense for the year 6,134 5,395Dividends to shareholders (2,793) (2,598)Shares issued 417 316Shares purchased and held as Treasury shares (3,537) (1,348)Shares purchased and cancelled (213) -Consideration received for shares transferred by ESOP Trusts 116 151Shares acquired by ESOP Trusts (26) -Share-based incentive plans 237 226Tax on share-based incentive plans 4 21Changes in minority interest shareholdings - 2Distributions to minority shareholders (77) (87) ---- ----Total equity at end of year 9,910 9,648 ---- ---- FINANCIAL REVIEW - BALANCE SHEET Net assets The book value of net assets increased by £262 million from £9,648 million at 31st December 2006 to £9,910 million at31st December 2007. This was attributable to a decrease in pension liabilities principally arising from an increase inthe rate used to discount UK pension liabilities from 5.0% to 5.75%, a further special contribution to the UK pensionschemes and some improvements in asset values, partially offset by changes in inflation and mortality rates. At 31stDecember 2007, the net deficit on the Group's pension plans was £156 million. The carrying value of investments in associates and joint ventures at 31st December 2007 was £329 million, with a marketvalue of £1 billion. On 18th December 2007, GSK acquired all of the share capital of Reliant Pharmaceuticals Inc., a pharmaceutical companybased in the USA, specialising in the development and marketing of speciality medicines to combat heart disease. Thepurchase price of £814 million, including acquisition costs, was represented by preliminary valuations of intangibleassets of £613 million, other net liabilities of £149 million and goodwill of £350 million. Equity At 31st December 2007, total equity had increased from £9,648 million at 31st December 2006 to £9,910 million. Theincrease arose principally from retained earnings and actuarial gains on defined benefit pension plans in the year andwas partially offset by further purchases of Treasury shares and shares purchased and cancelled. At 31st December 2007, the ESOP Trusts held 134.6 million GSK shares against the future exercise of share options andshare awards. The carrying value of £1,617 million has been deducted from other reserves. The market value of theseshares was £1,721 million. During the year, GSK repurchased £3,537 million of Treasury shares and purchased a further £213 million of shares forcancellation. At 31st December 2007, the company held 504.2 million Treasury shares at a cost of £6,683 million, whichhas been deducted from retained earnings. CASH FLOW STATEMENT Year ended 31st December 2007 2007 2006 £m £m ---- ----Profit after tax 5,310 5,498Tax on profits 2,142 2,301Share of after tax profits of associates and joint ventures (50) (56)Finance income/expense 191 65Depreciation and other non-cash items 1,333 1,138Increase in working capital (538) (471)Decrease in other net liabilities (308) (272) ---- ----Cash generated from operations 8,080 8,203 Taxation paid (1,919) (3,846) ---- ----Net cash inflow from operating activities 6,161 4,357 ---- ----Cash flow from investing activitiesPurchase of property, plant and equipment (1,516) (1,366)Proceeds from sale of property, plant and equipment 35 43Purchase of intangible assets (627) (224)Proceeds from sale of intangible assets 9 175Purchase of equity investments (186) (57)Proceeds from sale of equity investments 45 32Share transactions with minority shareholders - (157)Purchase of businesses, net of cash acquired (1,027) (273)Disposals of businesses and interests in associates - 5Investment in associates and joint ventures (1) (13)Interest received 247 299Dividends from associates and joint ventures 12 15 ---- ----Net cash outflow from investing activities (3,009) (1,521) ---- ----Cash flow from financing activitiesIncrease in liquid investments (39) (55)Proceeds from own shares for employee share options 116 151Shares acquired by ESOP Trusts (26) -Issue of share capital 417 316Purchase of own shares for cancellation (213) -Purchase of Treasury shares (3,538) (1,348)Increase in long-term loans 3,483 -Repayment of long-term loans (207) -Net increase in/(repayment of) short-term loans 1,632 (739)Net repayment of obligations under finance leases (39) (34)Interest paid (378) (414)Dividends paid to shareholders (2,793) (2,598)Dividends paid to minority interests (77) (87)Other financing cash flows (79) 16 ---- ----Net cash outflow from financing activities (1,741) (4,792) ---- ---- Increase/(decrease) in cash and bank overdrafts in the year 1,411 (1,956) Exchange adjustments 48 (254)Cash and bank overdrafts at beginning of year 1,762 3,972 ---- ----Cash and bank overdrafts at end of year 3,221 1,762 ---- ---- Cash and bank overdrafts at end of year comprise: Cash and cash equivalents 3,379 2,005 Overdrafts (158) (243) ---- ---- 3,221 1,762 ---- ---- CASH FLOW STATEMENT Three months ended 31st December 2007 Q4 2007 Q4 2006 £m £m ---- ----Profit after tax 1,076 1,205Tax on profits 455 505Share of after tax profits of associates and joint ventures (10) (13)Finance income/expense 67 3Depreciation and other non-cash items 413 251Increase in working capital (165) (11)Increase in other net liabilities 92 6 ---- ----Cash generated from operations 1,928 1,946 Taxation paid (544) (441) ---- ----Net cash inflow from operating activities 1,384 1,505 ---- ----Cash flow from investing activitiesPurchase of property, plant and equipment (474) (470)Proceeds from sale of property, plant and equipment 12 11Purchase of intangible assets (136) (69)Proceeds from sale of intangible assets 2 (8)Purchase of equity investments (28) (22)Proceeds from sale of equity investments - 10Share transactions with minority shareholders - 1Purchase of businesses, net of cash acquired (794) (256)Disposals of businesses and interests in associates - 2Investment in associates and joint ventures - (5)Interest received 39 102Dividends from associates and joint ventures 1 2 ---- ----Net cash outflow from investing activities (1,378) (702) ---- ----Cash flow from financing activitiesIncrease in liquid investments (20) (6)Proceeds from own shares for employee share options 12 31Shares acquired by ESOP Trusts (26) -Issue of share capital 49 55Purchase of own shares for cancellation (213) -Purchase of Treasury shares (1,208) (534)Increase in long-term loans 2,500 -Net increase in short-term loans 1,181 135Net repayment of obligations under finance leases (10) (7)Interest paid (99) (167)Dividends paid to shareholders (667) (620)Dividends paid to minority interests (8) (6)Other financing cash flows (2) 116 ---- ----Net cash inflow/(outflow) from financing activities 1,489 (1,003) ---- ---- Increase/(decrease) in cash and bank overdrafts in the period 1,495 (200) Exchange adjustments 49 (46)Cash and bank overdrafts at beginning of period 1,677 2,008 ---- ----Cash and bank overdrafts at end of period 3,221 1,762 ---- ---- Cash and bank overdrafts at end of period comprise: Cash and cash equivalents 3,379 2,005 Overdrafts (158) (243) ---- ---- 3,221 1,762 ---- ---- RECONCILIATION OF CASH FLOW TO MOVEMENTS IN NET DEBT 2007 2006 £m £m ---- ----Net debt at beginning of the year (2,450) (1,237) Increase/(decrease) in cash and bank overdrafts 1,411 (1,956)Cash outflow from liquid investments 39 55Net increase in long-term loans (3,276) -Net (increase in)/repayment of short-term loans (1,632) 739Net repayment of obligations under finance leases 39 34Exchange adjustments (88) (9)Other non-cash movements (82) (76) ---- ----Increase in net debt (3,589) (1,213) ---- ----Net debt at end of the year (6,039) (2,450) ---- ---- Short and long term borrowings have increased by approximately £5 billion as a result of the issuance of £2.5billion under the EMTN programme in Q4 2007 and other borrowing arrangements, principally to fund the new £12billion share buy-back programme announced in July 2007. FINANCIAL REVIEW - CASH FLOW Cash generated from operations was £8,080 million in 2007. This represents a decrease of £123 million compared with2006. The operating cash flow is in excess of the funds needed for the routine cash flows of tax, capital expenditureon property, plant and equipment and dividend payments to shareholders, together amounting to £6,228 million. Thepurchase of businesses, principally Domantis and Reliant, cost £1,027 million, net of cash acquired. Receipts of £533million arose from the exercise of share options: £116 million from shares held by the ESOP Trusts and £417 million fromthe issue of new shares. In addition, £3,538 million was spent in the year on purchasing Treasury shares and £213million on purchasing the company's shares for cancellation. Further issuances of £2.5 billion under the EMTN programmein Q4 2007 contributed to the increased cash position at 31st December 2007. EXCHANGE RATES The results and net assets of the Group, as reported in Sterling, are affected by movements in exchange rates betweenSterling and overseas currencies. GSK uses the average of exchange rates prevailing during the period to translate theresults and cash flows of overseas Group subsidiaries, associates and joint ventures into Sterling and period-end ratesto translate the net assets of those undertakings. The currencies which most influence these translations, and therelevant exchange rates, are: 2007 2006 Q4 2007 Q4 2006Average rates: ---- ---- ---- ---- £/US$ 2.00 1.85 2.03 1.94 £/Euro 1.46 1.47 1.40 1.50 £/Yen 235 215 229 227Period-end rates: £/US$ 1.99 1.96 1.99 1.96 £/Euro 1.36 1.48 1.36 1.48 £/Yen 222 233 222 233 During 2007, average sterling exchange rates were stronger against the US Dollar and the Yen compared with 2006.Comparing 2007 period-end rates with 2006 period-end rates, Sterling was also stronger against the US Dollar but weakeragainst the Euro and the Yen. LEGAL MATTERS The Group is involved in various legal and administrative proceedings; principally product liability, intellectualproperty, tax, anti-trust and governmental investigations and related private litigation concerning sales, marketing andpricing which are more fully described in the Legal proceedings note in the Annual Report. At 31st December 2007, the Group's aggregate provision for legal and other disputes (not including tax matters describedunder 'Taxation' on page 15) was £1.2 billion. The ultimate liability for legal claims may vary from the amountsprovided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations. Developments since the date of the Annual Report as previously updated by the Legal matters section of the ResultsAnnouncements for the first, second and third quarters of 2007 include: Intellectual property With respect to the Group's application for re-issue of its combination patent for Advair, the US Patent and TrademarkOffice re-issued that patent in February 2008. The re-issued patent covering the pharmaceutical composition claims hasthe same September 2010 expiration date as the original composition patent and will be listed in the register ofpharmaceutical patents maintained by the US Food and Drug Administration (FDA) (Orange Book). In February 2008, the Group filed an action in the US District Court for the Eastern District of Pennsylvania againstUnited Research Laboratories, Inc./Mutual Pharmaceuticals Company, Inc. in respect of the Group's patent relating to thecrystalline salt form of carvedilol, the active ingredient in Coreg CR. URL/Mutual had filed an Abbreviated New DrugApplication (ANDA) with the FDA with a certification of invalidity, unenforceability and non-infringement of the patentscovering the crystalline salt form and delayed release technology used for manufacturing that product which expire in2023 and 2016, respectively. FDA approval of that ANDA is stayed until the earlier of June 2010 or resolution of thepatent infringement action but in no event can such approval issue prior to the expiration of the data exclusivityperiod in April 2010. The case is in its early stages. In January 2008, the Group received a certification of invalidity, unenforceability and non-infringement from BarrLaboratories in respect of all three of its listed patents related to Avodart in connection with an ANDA filed by Barr.The basic patent covering the active ingredient in Avodart expires in November 2015; other patents covering the compoundgenerically and its use to treat benign prostate hyperplasia (BPH) expire in September 2013. Upon filing of aninfringement action later in February 2008, FDA approval of that ANDA would be stayed until the earlier of July 2010 orresolution of the patent infringement action. In December 2007, Encysive Pharmaceuticals Inc., Mitsubishi Kasei Corporation and the Group filed an action in the USDistrict Court for the Southern District of New York against Barr Laboratories, Inc. for infringement of Mitsubishi'spharmaceutical composition patent covering argatroban. Pursuant to a license from Mitsubishi, Encysive has developedargatroban for the treatment of heparin-induced thrombocytopenia and holds the New Drug Application approved by the FDA.Encysive has licensed the US marketing rights to argatroban to the Group. The Mitsubishi patent expires in June 2014.Barr had filed an ANDA with the FDA with a certification of invalidity, unenforceability and non-infringement of theMitsubishi patent. FDA approval of that ANDA is stayed until the earlier of May 2010 or resolution of the patentinfringement action. The case is in its early stages. In November 2007, the Group filed an action in the US District Court for the District of Delaware against TevaPharmaceuticals for infringement of one of its patents relating to Combivir. The patent, which covers the combinationof AZT and lamivudine to treat HIV, expires in May 2012. Teva had filed an ANDA with the FDA with a certification ofinvalidity, unenforceability and non-infringement of that combination patent. Teva did not challenge two other patentsrelating to Combivir that expire in 2010 and 2016. The case is in its early stages. Developments with respect to tax matters are described in 'Taxation' on page 15. ACCOUNTING PRESENTATION AND POLICIES This unaudited Results Announcement containing condensed financial information for the twelve and three months ended31st December 2007 is prepared in accordance with the Listing Rules of the UK Listing Authority, IAS 34 'InterimFinancial Reporting' and the accounting policies set out in the Annual Report 2006, except that the following newaccounting standards and interpretations have been implemented in 2007: • IFRS 7 'Financial instruments: disclosures'• Amendment to IAS 1 'Capital disclosures'• IFRIC 9 'Reassessment of embedded derivatives'• IFRIC 10 'Interim financial reporting and impairment'. None of these has had a material impact on the results of current or prior periods. In Q4 2007, GSK has introduced a 3-column approach to the income statement. 'Business Performance' shows GSK'sunderlying results excluding restructuring costs related to the new Operational Excellence programme announcedin October 2007 and significant acquisitions. There were no significant acquisition-related restructuring costsincurred in 2006 or 2007. The middle column shows restructuring costs and the 'Total' column shows the fullIFRS statutory results. Business performance, a supplemental non-IFRS measure, is the primary performance measure used by management,and is presented after excluding costs of the new Operational Excellence programme, which commenced in October2007, of £338 million (£261 million after tax). Management believes that exclusion of these items provides amore useful comparison of the Group's performance for the periods presented. Total results include these items.The Group reported only total results for 2006. In order to illustrate underlying performance, it is the Group's practice to discuss its results in terms ofconstant exchange rate (CER) growth. This represents growth calculated as if the exchange rates used todetermine the results of overseas companies in Sterling had remained unchanged from those used in the previousyear. All commentaries are presented in terms of CER and compare 2007 business performance results with 2006total results, unless otherwise stated. This Results Announcement does not constitute statutory accounts of the Group within the meaning of section 240of the Companies Act 1985. The 2007 financial statements have not yet been delivered to the Registrar, nor havethe auditors yet reported on them. The income statement, statement of recognised income and expense and cash flow statement for the year ended, and thebalance sheet at, 31st December 2006 have been derived from the full Group accounts published in the Annual Report 2006,which have been delivered to the Registrar of Companies and on which the report of the independent auditors wasunqualified and did not contain a statement under either section 237(2) or section 237(3) of the Companies Act 1985. Data for market share and market growth rates are GSK estimates based on the most recent data from independent externalsources and, where appropriate, are valued in Sterling at relevant exchange rates. Figures quoted for product marketshare reflect sales by GSK and licensees. INVESTOR INFORMATION Announcement of Annual Results for 2007 This Announcement was approved by the Board of Directors on Thursday 7th February 2008. The income statement, statement of recognised income and expense, and cash flow statement for the year ended 31stDecember 2007 and the balance sheet at that date, are subject to completion of the audit and may also change should asignificant adjusting event occur before the approval of the Annual Report 2007 on 27th February 2008. Financial calendar The company will announce first quarter 2008 results on 23rd April 2008. The first interim dividend for 2008 will havean ex-dividend date of 30th April 2008 and a record date of 2nd May 2008. It will be paid on 10th July 2008. Internet This Announcement and other information about GSK are available on the company's website at: http://www.gsk.com. This information is provided by RNS The company news service from the London Stock ExchangeRelated Shares:
Glaxosmithkline