Exercise of Options, Issue of Equity and TVR

8 October 2021

Diurnal Group plc

("Diurnal" or the "Company")

Exercise of Options, Issue of Equity and Total Voting Rights

Diurnal Group plc (AIM: DNL), the specialty pharmaceutical company targeting patient needs in chronic endocrine (hormonal) diseases, announces that it has issued 150,111 new ordinary shares of 5 pence each ("New Ordinary Shares") as a result of an exercise of options under the Company's Long Term Incentive Plan ("LTIP").

Application has been made for admission of the 150,111 New Ordinary Shares to trading on AIM, which is anticipated to occur at 8:00am on or around 12 October 2021 ("Admission"). The New Ordinary Shares will rank pari passu with the existing shares of common stock of the Company. Following Admission, the Company's issued ordinary share capital will consist of 169,053,801 ordinary shares. The Company does not hold any shares in treasury. Therefore, the total number of ordinary shares with voting rights in Diurnal following Admission will be 169,053,801.

The above figure of 169,053,801 may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in the Company under the FCA's Disclosure Guidance and Transparency Rules.

Notes to Editors

About Diurnal Group plc

Founded in 2004, Diurnal is a UK-headquartered, European specialty pharma company developing high quality products for the global market for the life-long treatment of chronic endocrine conditions, including congenital adrenal hyperplasia, adrenal insufficiency and hypogonadism. Its expertise and innovative research activities focus on circadian-based endocrinology to yield novel product candidates in the rare and chronic endocrine disease arena.

For further information about Diurnal, please visit www.diurnal.co.uk