Directors' interests in shares

BTG plc

25 July 2011

Directors' Interests in the shares of BTG plc

The following transactions have taken place in relation to the executive directors under the Company's share plans

1. Share release

The following shares in the Company have been released to Mr Rolf Soderstrom.

A special award of 76,448 shares was made under Section 9.4.2(2) to Mr Soderstrom on 22 July 2009, following the acquisition of Protherics PLC by BTG plc. Following testing of the performance conditions, 53,514 shares lapsed and the balance of 22,934 shares vested and was released to Rolf Soderstrom on 22 July 2011.

Following the sale of shares to meet tax and national insurance costs, Rolf Soderstrom's shareholding has increased by 10,966 to 90,823 shares, being 0.028% of the issued share capital. The shares were sold at 291.60p per share.

2. Share awards

(a) On 6 July 2011 the Company made the following grants of share options in BTG plc under the BTG Executive Share Option Plan 2009 at an exercise price of 298.90p, the closing mid market price on 6 July:

Louise Makin 153,320

Rolf Soderstrom 99,658

The options will normally be capable of exercise three years after the date of grant, subject to continued employment and the satisfaction of performance conditions as set out below. The awards represent 100% of salary calculated at the exercise price. The number of shares that will be exercisable will depend on the extent to which the performance conditions are achieved.

(b) On 6 July 2011 the Company made the following conditional awards of shares in BTG plc under the Performance Share Plan 2006:

Louise Makin 159,867

Rolf Soderstrom 103,913

The awards will normally vest after three years, subject to continued employment and the satisfaction of performance conditions as set out below. The awards represent 100% of salary calculated at 286.66p (being the average of five days' closing mid-market share prices ending on 6 July). The number of shares that will vest will depend on the extent to which the performance conditions are achieved.

(c) On 4 July 2011 the Company approved the grant of 822 BTG plc shares to Louise Makin under the BTG Sharesave Plan 2009. The grant will be exercisable on 1 September 2014 at a price of 219.52p (being the average of the closing mid-market share prices on 8 - 10 June 2011 less 20%), assuming the three-year savings contract is completed and subject to continued employment.

(d) The Company has awarded bonuses to its executive directors. Of the bonuses, 50% is payable in cash with the balance being awarded in shares under the Company's Deferred Share Bonus Plan. Under the terms of the Plan, these shares will normally be released in full to the directors only after a further three years service.

The shares were awarded on 6 July 2011, calculated at 286.66p (being the average of five days' closing mid-market share prices ending on 6 July). The number of shares awarded was as follows:

Louise Makin 53,288

Rolf Soderstrom 34,637

3. Performance conditions

·; The performance conditions for both the share options and performance shares are based on Trading Profit and Total Shareholder Return targets in equal proportions over a fixed three-year period.

·; The balance of shares that do not vest at the end of the three-year period, following the testing of the performance conditions, will lapse at that time.

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Contact for Queries: Andy Burrows

Telephone: 020 7575 1741