Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

The interest of David Smith, a person discharging managerial responsibilities, in AstraZeneca ordinary shares, has changed as detailed below.

On 23 August 2012, Mr Smith exercised options over 36,131 and 33,333 AstraZeneca ordinary shares at option prices of 1882 pence per share and 2280 pence per share respectively.

Following these exercises, Mr Smith sold 58,259 of the 69,464 shares so acquired at a price of 2968 pence per share to cover the cost of exercise and associated taxes.

A C N Kemp

Company Secretary

24 August 2012