Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rules DTR 3.1.4R

We hereby inform you that the interest of David Brennan, a Director of the Company, in the shares of AstraZeneca PLC has changed as detailed below.

On 18 February 2011, Mr Brennan exercised an option over 29,354 AstraZeneca PLC American Depositary Shares (ADSs) at an option price of $47.14 per ADS and an option over 39,942 ADSs at an option price of $47.73 per ADS. One ADS equals one Ordinary Share. The options, which were granted to Mr Brennan in March 2001 and June 2001 respectively, were due to expire in March 2011 and June 2011, if not exercised before then.

Following these exercises, Mr Brennan sold all of the 69,296 ADSs so acquired at a price of $49.10 per ADS.

As a result of this transaction, Mr Brennan holds options over 252,223 ADSs and 592,975 Ordinary Shares.

Following this transaction, Mr Brennan has an interest in 607,699 Ordinary Shares and 78,469 AstraZeneca ADSs, which together represent approximately 0.05% of the Company's issued ordinary capital.

A C N Kemp

Company Secretary

21 February 2011