Director/PDMR Shareholding

Director/PDMR Share Dealings October 24, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesit was notified today that Flemming Ornskov, MD, Chief Executive Officer of theCompany, acquired 15,500 ordinary shares of 5 pence each in the Company("Shares") today at an average price of £40.42 per share. The transaction tookplace on the London Stock Exchange. Following the above transaction, Dr Ornskov holds 37,500 Shares. He also holdsawards of Stock Appreciation Rights, Performance Shares and Deferred Sharesover 187,401 ADSs. One ADS is equal to three Shares. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor RelationsJeff Poulton [email protected] +1 781 482 0945Sarah Elton-Farr [email protected] +44 1256 894157 MediaStephanie Fagan [email protected] +1 781 482 0460Gwen Fisher [email protected] +1 484 595 9836 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com