Director/PDMR Shareholding

Director/PDMR Shareholding March 6, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces itwas notified today that on March 5, 2014, Phil Vickers, a Person DischargingManagerial Responsibility, sold 1,151 American Depositary Shares in the Company("ADSs") at an average sale price of $169.3135. The ADSs were sold on theNASDAQ Global Select Market. One ADS is equal to three Ordinary Shares. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Laurie Stelzer [email protected] +1 781 482 0733 Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com