Director/PDMR Shareholding

Director/PDMR Share Dealings March 31, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat today Ordinary Shares ("Shares") and American Depository Shares ("ADSs")of the Company, as set out below, have been acquired for the Non-ExecutiveDirectors, being the part of their total fees that are paid in securities forthe period of service from January 1 to March 31, 2014. Type of Security (1) Number of Securities Dominic Blakemore Shares 147 William Burns Shares 178 Dr. Steven Gillis ADSs 57 Dr. David Ginsburg ADSs 54 David Kappler Shares 186 Susan Kilsby ADSs 61 Anne Minto Shares 185 David Stout ADSs 59 (1) One ADS is equal to three Shares The Shares and ADSs were acquired on the London Stock Exchange and NASDAQrespectively at prices of £29.9876 per Share and $147.90 per ADS. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Laurie Stelzer [email protected] +1 781 482 0733 Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com