25th Aug 2006 12:00
25 August 2006Shire plc (the "Company")Notification of the Exercise of an Option and Sale of Shares by a PersonDischarging Managerial ResponsibilitiesThe Company announces that on 24 August 2006 it was notified of the exercise inLondon on the same day by Mr Joseph Rus, Executive Vice President - AllianceManagement & New Market Development, of an option over 66,038 ordinary 5pshares in the capital of the Company at an exercise price of ‚£3.38 and anoption over 35,965 ordinary 5p shares in the capital of the Company at anexercise price of ‚£5.25.The Company further announces that on 24 August 2006 it was notified of thesale in London on the same day by Mr Rus of the same 102,003 ordinary 5p sharesin the capital of the Company at a price of ‚£8.91.Following these transactions, Mr Rus holds options over 261,845 ordinary 5pshares in the capital of the Company.T MayCompany SecretaryFor further information please contact:Investor Relations Clƒ©a Rosenfeld (Rest of the World) +44 1256 894 160 Brian Piper (North America) +1 484 595 8252 Notes to editorsSHIRE PLCShire's strategic goal is to become the leading specialty pharmaceuticalcompany that focuses on meeting the needs of the specialist physician. Shirefocuses its business on attention deficit and hyperactivity disorder (ADHD),human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. Thestructure is sufficiently flexible to allow Shire to target new therapeuticareas to the extent opportunities arise through acquisitions. Shire believesthat a carefully selected portfolio of products with a strategically alignedand relatively small-scale sales force will deliver strong results.Shire's focused strategy is to develop and market products for specialtyphysicians. Shire's in-licensing, merger and acquisition efforts are focused onproducts in niche markets with strong intellectual property protection eitherin the US or Europe.For further information on Shire, please visit the Company's website: www.shire.com. Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release Registered in England 2883758 Registered Office as aboveENDSHIRE PLCRelated Shares:
Shire