Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 6 December 2012, Jeff Pott, a person discharging managerial responsibility, exercised options over 35,264 AstraZeneca American Depositary Shares (ADSs) as follows:

16,933 ADSs at an option price of $37.76 per ADS.

9,351 ADSs at an option price of $40.35 per ADS.

8,980 ADSs at an option price of $46.63 per ADS.

One ADS equals one ordinary share.

Following these exercises, Mr Pott sold 32,940 of the ADSs so acquired at a price of $48.03 per ADS.

A C N Kemp

Company Secretary

7 December 2012