Director/PDMR Shareholding

Director Share Dealings November 1, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that onNovember 1, 2013, Flemming Ornskov was granted an option over AmericanDepository Shares ("ADSs") pursuant to the Shire Employee Stock Purchase Plan.He has elected to save US$480.76 per fortnight. The option price will be thelower of 85% of the fair market value of an ADS on November 1, 2013, and 85% ofthe fair market value of an ADS on the exercise date, October 31, 2014. One ADSis equal to three Shire ordinary shares of 5 pence each. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com 2 Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com