Director/PDMR Shareholding

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

We hereby inform you that on 29 July 2010, the interest of Tony Zook, a person discharging managerial responsibilities, in the shares of AstraZeneca PLC has changed as detailed below. Tony Zook has interests in the American Depositary Shares (ADSs) of AstraZeneca PLC. One ADS equals one Ordinary Share. 

Tony Zook exercised options over 23,555 ADSs (the "Subject ADSs") granted on 26 March 2004 at a grant price of $46.63.

Tony Zook subsequently sold the Subject ADSs at an exercise price of $50.81012

A C N Kemp

Company Secretary

30 July 2010