Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 3 January 2012, we were notified that David Smith, a person discharging managerial responsibility, exercised an option over 545 AstraZeneca shares on 28 December 2011. The option was granted to Mr Smith in 2006 under the AstraZeneca Savings Related Share Option Plan at an option price of 3001 pence per share.

Following the exercise, Mr Smith transferred the 545 shares to Mrs Alison Smith, a person connected with Mr Smith.

A C N Kemp

Company Secretary

4 January 2012