Director/PDMR Shareholding

Director/PDMR Share Dealings June 28, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announcesthat today Ordinary Shares ("Shares") and American Depository Shares ("ADSs")of the Company, as set out below, have been acquired for the Non-ExecutiveDirectors, being the part of their total fees that are paid in shares for theperiod of service from April 1 to June 30, 2013. Type of Security (1) Number of Shares/ADSs William Burns Shares 243 Dr. Steven Gillis ADSs 78 Dr. David Ginsburg ADSs 73 David Kappler Shares 288 Susan Kilsby ADSs 74 Anne Minto Shares 253 David Stout ADSs 81 (1) One ADS is equal to three Shares The Shares and ADSs were acquired on the London Stock Exchange and NASDAQrespectively, at prices of £20.90 per Share and $95.20 per ADS. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com