Director/PDMR Shareholding

Director/PDMR Share Dealings January 8, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesit has been notified that Dr. Steven Gillis, Non-Executive Director of theCompany, was recently informed that American Depositary Shares ("ADSs"), as setout below, were acquired on his account by an independent third partyexercising discretion over dealing decisions. The transactions took place onthe NASDAQ. Date of Number of ADSs Average price per ADS transaction acquired October 30, 2014 127 $196.744 December 19, 2014 76 $218.16 Following the above transactions, Dr. Gillis holds 674 ADSs. One ADS is equalto three ordinary shares of 5 pence each in the Company. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules ("DTRs"). In accordance with 3.1.5(R)of the DTRs, the information required to be included in this notification wasreceived by the Company today, January 8, 2015. For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com