Director/PDMR Shareholding

Press Release www.shire.com Director/PDMR Shareholding March 11, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesit was notified today that Jeff Poulton, Chief Financial Officer of theCompany, was granted a Restricted Stock award (the "Award") today under theShire Deferred Bonus Plan 2015 ("DBP"). The Award, which is in respect of 560American Depositary Shares ("ADSs"), will normally vest after three years. TheADSs were acquired today on the NASDAQ Global Select Market at an average priceof $163.0237 per ADS. The DBP is a sub-plan of the Shire Long Term Incentive Plan 2015. The DBP hasreplaced the Shire Executive Annual Incentive Plan as referenced in the 2014Annual Report and Accounts. One ADS is equal to three Ordinary Shares of 5pence each in the Company. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure Rules and Transparency Rules. Oliver StrawbridgeSenior Assistant Company Secretary For further information please contact: Investor RelationsSarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX END