Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

The interest of Ruud Dobber, a person discharging managerial responsibilities, in AstraZeneca PLC Ordinary Shares of $0.25 each, has changed as detailed below.

On 30 April 2013, Mr Dobber exercised an option over 10,005 AstraZeneca ordinary shares at an option price of 2975 pence per share.

Following the exercise, Mr Dobber sold 9,509 of the 10,005 shares so acquired at a price of 3366 pence per share to cover the cost of exercise and associated taxes. He retained the balance of 496 shares.

A C N Kemp

Company Secretary

1 May 2013