Director/PDMR Shareholding

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

We hereby inform you that on 29 January 2010, Mr John Varley, a Director of the Company, notified us that, on 29 January 2010, he purchased 300 AstraZeneca PLC USD0.25 Ordinary Shares at a price of 2922 pence per share.

Following this purchase, Mr Varley has a total interest in 800 shares, which represents approximately 0.00006% of the issued ordinary capital of the Company.

A C N Kemp

Company Secretary

1 February 2010