Director/PDMR Shareholding

SHIRE PLC - Director/PDMR Shareholding

PR Newswire

London, February 26

Director/PDMR Shareholding

February 26, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces it was notified today that Sara Mathew, Non-Executive Director of the Company, acquired 1,000 American Depositary Shares (“ADSs”) today at an average price of $163.00 per ADS. The transaction took place on the NASDAQ Global Select Market. One ADS is equal to three Ordinary Shares of 5 pence each in the Company.

This notification is to satisfy the Company’s obligations under 3.1.4(R)(1)(a) of the Disclosure Rules and Transparency Rules.

Oliver Strawbridge

Senior Assistant Company Secretary

For further information please contact:

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

www.shire.com