Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rules DTR 3.1.4R

We hereby inform you that the interest of Simon Lowth, a Director of the Company, in the ordinary shares of AstraZeneca PLC has changed as detailed below.

On 3 February 2012, Mr Lowth sold 22,278 shares at a price of 2985 pence per share for reasons of personal financial planning.

As a result of this transaction, Mr Lowth has an interest in 239,085 shares, which represent approximately 0.02% of the Company's issued ordinary capital.

A C N Kemp

Company Secretary

3 February 2012