Director/PDMR Shareholding

Director Share Dealings November 14, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces it wasnotified today that Flemming Ornskov, MD, Chief Executive Officer of theCompany, acquired 22,000 ordinary shares of 5 pence each in the Company("Shares") on November 13, 2013 at an average price of £28.19 per share. Thetransaction took place on the London Stock Exchange. Following the above transaction, Dr Ornskov holds 22,000 Shares. He also holdsawards of Stock Appreciation Rights, Performance Shares and Deferred Sharesover 124,893 ADSs. One ADS is equal to three Shares. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com