Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 19 December 2013, Marc Dunoyer, a Director of the Company notified us that, on 19 December 2013, he purchased 500 AstraZeneca PLC Ordinary Shares of $0.25 each at a price of 3601 pence per share.

Under the Company's Articles of Association, by way of qualification, a Director is required to be the beneficial owner of 500 Ordinary Shares of the Company, such shares to be obtained within two months of the date of his appointment. Mr Dunoyer was appointed a Director on 1 November 2013.

Following this purchase, Mr Dunoyer has a total interest, including an interest under certain of the Company's share plans, in 165,034 AstraZeneca shares.

A C N Kemp

Company Secretary

19 December 2013