Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

We hereby inform you that on 15 November 2010, Michele Hooper, a Director of the Company, notified us that, on 15 November 2010, she purchased 700 AstraZeneca PLC American Depositary Shares (ADSs) at a price of $48.55 per ADS. One ADS equals one Ordinary Share.

Following this purchase, Michele Hooper has a total interest in 2,400 shares, which represents approximately 0.0002% of the issued ordinary capital of the Company.

A C N Kemp

Company Secretary

16 November 2010