Director/PDMR Shareholding

1.

Details of the person discharging managerial responsibilities / person closely associated

a.

Name

1. Dr Ian Gilham

2. David Budd

3. John Rylands

4. Dr Allan Brown

5. Dr Roger Lloyd

2.

Reason for the notification

a.

Position/status

1. Non-Executive Chairman

2. Chief Executive Officer

3. Chief Financial Officer

4. Non-Executive Director

5. Non-Executive Director

a.

Initial notification

/Amendment

Initial notification

3.

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a.

Name

Epistem Holdings plc

b.

LEI

N/A

4.

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a.

Description of the

Financial instrument, type

of instrument

Identification code

Ordinary shares of 1.5 pence each

b.

Nature of the transaction

Settlement of placing shares purchased as announced on 23 June 2016

c.

Price(s) and volume(s)

d.

Aggregated information

· Aggregated volume

· Price

N/A

e.

Date of the transaction

2016-07-12; UTC time

f.

Place of the transaction

AIM Market of the London Stock Exchange