Director/PDMR Shareholding

Director/PDMR Share Dealings June 30, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat today Ordinary Shares ("Shares") and American Depository Shares ("ADSs")of the Company, as set out below, have been acquired for the Non-ExecutiveDirectors, being the part of their total fees that are paid in shares for theperiod of service from April 1 to June 30, 2014. Type of Security (1) Number of Shares/ADSs Dominic Blakemore Shares 101 William Burns Shares 115 Dr. Steven Gillis ADSs 36 Dr. David Ginsburg ADSs 34 David Kappler Shares 120 Susan Kilsby ADSs 91 Anne Minto Shares 120 David Stout ADSs 37 (1) One ADS is equal to three Shares The Shares and ADSs were acquired on the London Stock Exchange and NASDAQrespectively at prices of £46.50 per Share and $235.50 per ADS. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com