Director/PDMR Share Dealings

Press Release www.shire.com Director/PDMR Share Dealings November 3, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat today the following Persons Discharging Managerial Responsibility("PDMRs") acquired American Depositary Shares ("ADSs") in the Company under theShire Employee Stock Purchase Plan: PDMR Exercise price per ADS Number of ADSs Flemming Ornskov $113.94 109 Mark Enyedy $113.94 109 Philip Vickers $113.94 109 One ADS is equal to three Ordinary Shares of 5 pence each. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor RelationsJeff Poulton [email protected] +1 781 482 0945Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX