Director/PDMR Share Dealings

Director/PDMR Share Dealings March 31, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat Ordinary Shares ("Shares") and American Depositary Shares ("ADSs") of theCompany, as set out below, have been acquired today for the Non-ExecutiveDirectors, being the part of their total fees that are paid in shares for theperiod of service from January 1 to March 31, 2015. Type of Security(1) Number of Shares/ADSs Dominic Blakemore Shares 100 William Burns Shares 118 Dr. Steven Gillis ADSs 41 Dr. David Ginsburg ADSs 35 David Kappler Shares 118 Susan Kilsby ADSs 125 Anne Minto Shares 121 David Stout ADSs 36 (1) One ADS is equal to three Shares The Shares and ADSs were acquired on the London Stock Exchange and NASDAQrespectively at £54.3489 per Share and $237.20 per ADS. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor RelationsSarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com