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Director/PDMR Share Dealings

29th Feb 2012 18:20

Director/PDMR Share Dealings

February 29, 2012 - Shire plc , the global specialty biopharmaceutical company, announces that on February 28, 2012 the following Persons Discharging Managerial Responsibility ("PDMRs") were granted awards under the Shire Portfolio Share Plan (PSP).

Stock Appreciation Right Awards ("SAR Awards") under Part A of the PSP

SAR Awards will normally vest after three years, subject to any performance targets having been satisfied. No consideration is payable for these awards.

Type of Security1 No of Ordinary Exercise price Shares/ADSs Angus Russell 2 ADSs 47,861 $105.50 Graham Hetherington 2 Ordinary Shares 55,554 £22.22 Michael Cola ADSs 9,683 $105.50 Barbara Deptula ADSs 5,645 $105.50 Sylvie Gregoire ADSs 10,409 $105.50 Tatjana May Ordinary Shares 20,180 £22.22 Kevin Rakin ADSs 6,778 $105.50

Performance Share Awards ("PSA Awards") under Part B of the PSP

PSA Awards will normally vest after three years, subject to any performance targets having been satisfied. No consideration is payable for these awards.

Type of Security No of Ordinary 1 Shares/ADSs Angus Russell 2 ADSs 35,896 Graham Hetherington 2 Ordinary Shares 40,740 Michael Cola ADSs 7,101 Barbara Deptula ADSs 4,064 Sylvie Gregoire ADSs 7,633 Tatjana May Ordinary Shares 14,530 Kevin Rakin ADSs 4,971

1. One ADS is equal to three Shire ordinary shares.

2. Vesting of awards granted to Executive Directors is subject to performance targets.

This notification is made to satisfy the Company's obligations under 3.1.4(R) (1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie

Deputy Company Secretary

For further information please contact:

Investor Eric Rojas [email protected] +1 781 482 0999 Relations Sarah Elton-Farr [email protected] +44 1256 894157

Notes to editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder, human genetic therapies, gastrointestinal diseases and regenerative medicine as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

XLON

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