Director/PDMR Share Dealings

Director/PDMR Share Dealings February 13, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")announces that it has been notified today that Ordinary Shares ("Shares") andAmerican Depositary Shares ("ADSs") of the Company, as set out below, have beenawarded to Persons Discharging Managerial Responsibilities ("PDMRs") todayunder the Shire Executive Annual Incentive Plan ("EAIP") and under deferredstock arrangements related to Shire's annual bonus plan ("Deferred Bonus"). TheShares and ADSs were acquired today at prices of £50.10 per Share and $233.639per ADS on the London Stock Exchange and NASDAQ respectively. PDMR Award Arrangement Type of Security Number of Securities Flemming Ornskov EAIP ADSs 2,501 Tatjana May EAIP Shares 1,744 Mark Enyedy Deferred Bonus ADSs 455 Ginger Gregory Deferred Bonus ADSs 330 Philip Vickers Deferred Bonus ADSs 450 The awards will normally be released to PDMRs after a period of three years.One ADS is equal to three Shares. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com